7AAY
Crystal structure of MerTK kinase domain in complex with Merestinib
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Tyrosine-protein kinase Mer | polymer | 294 | 33836.2 | 1 | UniProt (Q12866) Pfam (PF07714) | Homo sapiens (Human) | Proto-oncogene c-Mer,Receptor tyrosine kinase MerTK |
| 2 | B (A) | N-(3-fluoro-4-{[1-methyl-6-(1H-pyrazol-4-yl)-1H-indazol-5-yl]oxy}phenyl)-1-(4-fluorophenyl)-6-methyl-2-oxo-1,2-dihydropyridine-3-carboxamide | non-polymer | 552.5 | 1 | Chemie (L1X) | |||
| 3 | C, D, E (A) | CHLORIDE ION | non-polymer | 35.5 | 3 | Chemie (CL) | |||
| 4 | F (A) | water | water | 18.0 | 117 | Chemie (HOH) |
Sequence modifications
A: 571 - 864 (UniProt: Q12866)
| PDB | External Database | Details |
|---|---|---|
| Gly 567 | - | expression tag |
| Ser 568 | - | expression tag |
| His 569 | - | expression tag |
| Met 570 | - | expression tag |
| - | Met 659 | deletion |
| - | Ser 660 | deletion |
| - | Ser 661 | deletion |
| - | Gln 662 | deletion |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 33836.2 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 658.9 | |
| All* | Total formula weight | 34495.1 |
