7A8Q
Crystal structure of human phosphodiesterase 4D2 catalytic domain with inhibitor NPD-654
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | polymer | 364 | 41808.2 | 4 | UniProt (Q08499) Pfam (PF00233) | Homo sapiens (Human) | DPDE3,PDE43 |
| 2 | AA, E, JA, Q (C, A, D, B) | ZINC ION | non-polymer | 65.4 | 4 | Chemie (ZN) | |||
| 3 | BA, F, KA, R (C, A, D, B) | MAGNESIUM ION | non-polymer | 24.3 | 4 | Chemie (MG) | |||
| 4 | CA, DA, EA, G, H... (C, A, D, B) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 27 | Chemie (EDO) | |||
| 5 | FA, N, Y, YA, Z (C, A, B, D) | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID | non-polymer | 238.3 | 5 | Chemie (EPE) | |||
| 6 | GA, UA, X (C, D, B) | 2-cycloheptyl-5-[4-methoxy-3-[[4-(1~{H}-1,2,3,4-tetrazol-5-yl)phenyl]methoxy]phenyl]-4,4-dimethyl-pyrazolidin-3-one | non-polymer | 490.6 | 3 | Chemie (R4H) | |||
| 7 | HA, VA, WA, XA (C, D) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 4 | Chemie (PEG) | |||
| 8 | AB, BB, CB, ZA (B, C, D, A) | water | water | 18.0 | 467 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 79 - 438 (UniProt: Q08499)
| PDB | External Database | Details |
|---|---|---|
| Gly 75 | - | expression tag |
| Ser 76 | - | expression tag |
| His 77 | - | expression tag |
| Met 78 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 167233.0 | |
| Non-Polymers* | Number of molecules | 47 |
| Total formula weight | 5122.5 | |
| All* | Total formula weight | 172355.5 |
