7A6K
Crystal Structure of EGFR-T790M/V948R in Complex with TAK-788
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D | Epidermal growth factor receptor | polymer | 333 | 37963.9 | 4 | UniProt (P00533) Pfam (PF07714) In PDB | Homo sapiens (Human) | Proto-oncogene c-ErbB-1,Receptor tyrosine-protein kinase erbB-1 |
| 2 | A, B, C, D | propan-2-yl 2-[[4-[2-(dimethylamino)ethyl-methyl-amino]-2-methoxy-5-(propanoylamino)phenyl]amino]-4-(1-methylindol-3-yl)pyrimidine-5-carboxylate | non-polymer | 587.7 | 4 | Chemie (R28) | |||
| 3 | B, C, D | SULFATE ION | non-polymer | 96.1 | 7 | Chemie (SO4) | |||
| 4 | water | water | 18.0 | 137 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 695 - 1022 (UniProt: P00533)
| PDB | External Database | Details |
|---|---|---|
| Gly 690 | - | expression tag |
| Ser 691 | - | expression tag |
| His 692 | - | expression tag |
| Met 693 | - | expression tag |
| Ala 694 | - | expression tag |
| Met 790 | Thr 790 | engineered mutation |
| Arg 948 | Val 948 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 151855.6 | |
| Non-Polymers* | Number of molecules | 11 |
| Total formula weight | 3023.3 | |
| All* | Total formula weight | 154878.9 |
