7A6I
Crystal Structure of EGFR-T790M/V948R in Complex with LDC8201
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Epidermal growth factor receptor | polymer | 333 | 37963.9 | 1 | UniProt (P00533) Pfam (PF07714) In PDB | Homo sapiens (Human) | Proto-oncogene c-ErbB-1,Receptor tyrosine-protein kinase erbB-1 |
2 | A | SULFATE ION | non-polymer | 96.1 | 4 | Chemie (SO4) | |||
3 | A | ~{N}-[5-[4-chloranyl-2-[4-(4-methylpiperazin-1-yl)phenyl]-1~{H}-pyrrolo[2,3-b]pyridin-3-yl]-2-methyl-phenyl]propanamide | non-polymer | 488.0 | 1 | Chemie (R1W) | |||
4 | water | water | 18.0 | 21 | Chemie (HOH) |
Sequence modifications
A: 695 - 1022 (UniProt: P00533)
PDB | External Database | Details |
---|---|---|
Gly 690 | - | expression tag |
Ser 691 | - | expression tag |
His 692 | - | expression tag |
Met 693 | - | expression tag |
Ala 694 | - | expression tag |
Met 790 | Thr 790 | engineered mutation |
Arg 948 | Val 948 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 37963.9 | |
Non-Polymers* | Number of molecules | 5 |
Total formula weight | 872.3 | |
All* | Total formula weight | 38836.2 |