7A6F
Nanodisc reconstituted human ABCB1 in complex with MRK16 Fab and zosuquidar
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Multidrug resistance protein 1 | polymer | 1280 | 141628.8 | 1 | UniProt (P08183) Pfam (PF00664) Pfam (PF00005) In PDB | Homo sapiens (Human) | ATP-binding cassette sub-family B member 1,P-glycoprotein 1 |
| 2 | B | MRK16 Fab-fragment light chain | polymer | 219 | 24139.8 | 1 | Mus musculus (House mouse) | ||
| 3 | C | MRK16 Fab-fragment heavy chain | polymer | 218 | 23415.2 | 1 | Mus musculus (House mouse) | ||
| 4 | A | Zosuquidar | non-polymer | 527.6 | 2 | Chemie (ZQU) | |||
| 5 | A | CHOLESTEROL | non-polymer | 386.7 | 8 | Chemie (CLR) |
Sequence modifications
A: 1 - 1280 (UniProt: P08183)
| PDB | External Database | Details |
|---|---|---|
| Ala 893 | Ser 893 | variant |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 189183.8 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 4148.4 | |
| All* | Total formula weight | 193332.2 |
