7A6C
Nanodisc reconstituted human ABCB1 in complex with MRK16 Fab and elacridar
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Multidrug resistance protein 1 | polymer | 1280 | 141628.8 | 1 | UniProt (P08183) Pfam (PF00664) Pfam (PF00005) In PDB | Homo sapiens (Human) | ATP-binding cassette sub-family B member 1,P-glycoprotein 1 |
| 2 | B | If kappa light chain | polymer | 219 | 24139.8 | 1 | UniProt (A2NHM3) Pfam (PF07686) Pfam (PF07654) In PDB | Mus musculus (Mouse) | |
| 3 | C | MRK16 Fab-fragment heavy chain | polymer | 218 | 23415.2 | 1 | Mus musculus (House mouse) | ||
| 4 | A | elacridar | non-polymer | 563.6 | 2 | Chemie (R0Z) | |||
| 5 | A | CHOLESTEROL | non-polymer | 386.7 | 10 | Chemie (CLR) |
Sequence modifications
A: 1 - 1280 (UniProt: P08183)
B: 1 - 220 (UniProt: A2NHM3)
| PDB | External Database | Details |
|---|---|---|
| Ala 893 | Ser 893 | variant |
| PDB | External Database | Details |
|---|---|---|
| Val 9 | Leu 9 | conflict |
| Ser 12 | Pro 12 | conflict |
| Ser 32 | Thr 32 | conflict |
| Thr 33 | Asn 33 | conflict |
| Ile 56 | Val 56 | conflict |
| Ala 96 | Gly 96 | conflict |
| Ala 99 | Val 99 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 189183.8 | |
| Non-Polymers* | Number of molecules | 12 |
| Total formula weight | 4993.8 | |
| All* | Total formula weight | 194177.6 |
