7A5B

Structure of DYRK1A in complex with complex 10

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Dual specificity tyrosine-phosphorylation-regulated kinase 1A	polymer	382	44553.2	2	UniProt (Q13627) Pfam (PF00069)	Homo sapiens (Human)	Dual specificity YAK1-related kinase,HP86,Protein kinase minibrain homolog,hMNB
2	C, D (A, B)	4-(4-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-2-amine	non-polymer		241.2	2	Chemie (MFR)
3	E, F (A, B)	water	water		18.0	267	Chemie (HOH)

Sequence modifications

A, B: 127 - 485 (UniProt: Q13627)

PDB	External Database	Details
Met 104	-	initiating methionine
His 105	-	expression tag
His 106	-	expression tag
His 107	-	expression tag
His 108	-	expression tag
His 109	-	expression tag
His 110	-	expression tag
Ser 111	-	expression tag
Ser 112	-	expression tag
Gly 113	-	expression tag
Val 114	-	expression tag
Asp 115	-	expression tag
Leu 116	-	expression tag
Gly 117	-	expression tag
Thr 118	-	expression tag
Glu 119	-	expression tag
Asn 120	-	expression tag
Leu 121	-	expression tag
Tyr 122	-	expression tag
Phe 123	-	expression tag
Gln 124	-	expression tag
Ser 125	-	expression tag
Met 126	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	89106.4
Non-Polymers*	Number of molecules	2
	Total formula weight	482.5
All*	Total formula weight	89588.9

*Water molecules are not included.