7A54

Two copies of the catalytic domain of NanA sialidase from Streptococcus pneumoniae juxtaposed in the P212121 space group, in complex with DANA

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Sialidase A	polymer	498	56141.6	2	UniProt (P62575)	Streptococcus pneumoniae	Neuraminidase A
2	C, D (A, B)	2-DEOXY-2,3-DEHYDRO-N-ACETYL-NEURAMINIC ACID	non-polymer		291.3	2	Chemie (DAN) PubChem (1553) PubChem (65309) PubChem (196123) PubChem (440392) PubChem (492456) PubChem (13728878) PubChem (44299597) PubChem (44305374) PubChem (44314809) PubChem (44353094) PubChem (44387099) PubChem (44629965) PubChem (49819354) PubChem (50986297) PubChem (68019401) PubChem (5329058) PubChem (57673682) PubChem (15956564) PubChem (71299570) PubChem (71312796) PubChem (93616863) PubChem (101008065) PubChem (102094437) PubChem (132002898) PubChem (133688885)
3	E, F (A, B)	water	water		18.0	263	Chemie (HOH)

Sequence modifications

A, B: 303 - 776 (UniProt: P62575)

PDB	External Database	Details
Met 279	-	initiating methionine
Gly 280	-	expression tag
His 281	-	expression tag
His 282	-	expression tag
His 283	-	expression tag
His 284	-	expression tag
His 285	-	expression tag
His 286	-	expression tag
His 287	-	expression tag
His 288	-	expression tag
His 289	-	expression tag
His 290	-	expression tag
Ser 291	-	expression tag
Ser 292	-	expression tag
Gly 293	-	expression tag
His 294	-	expression tag
Ile 295	-	expression tag
Asp 296	-	expression tag
Asp 297	-	expression tag
Asp 298	-	expression tag
Asp 299	-	expression tag
Lys 300	-	expression tag
His 301	-	expression tag
Met 302	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	112283.2
Non-Polymers*	Number of molecules	2
	Total formula weight	582.5
All*	Total formula weight	112865.7

*Water molecules are not included.