7A4W
Structure of DYRK1A in complex with compound 3
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Dual specificity tyrosine-phosphorylation-regulated kinase 1A | polymer | 382 | 44553.2 | 2 | UniProt (Q13627) Pfam (PF00069) In PDB | Homo sapiens (Human) | Dual specificity YAK1-related kinase,HP86,Protein kinase minibrain homolog,hMNB |
2 | A, B | 6-(4-methoxyphenyl)pyrimidine-2,4-diamine | non-polymer | 216.2 | 2 | Chemie (QYH) | |||
3 | water | water | 18.0 | 245 | Chemie (HOH) |
Sequence modifications
A, B: 127 - 485 (UniProt: Q13627)
PDB | External Database | Details |
---|---|---|
Met 104 | - | initiating methionine |
His 105 | - | expression tag |
His 106 | - | expression tag |
His 107 | - | expression tag |
His 108 | - | expression tag |
His 109 | - | expression tag |
His 110 | - | expression tag |
Ser 111 | - | expression tag |
Ser 112 | - | expression tag |
Gly 113 | - | expression tag |
Val 114 | - | expression tag |
Asp 115 | - | expression tag |
Leu 116 | - | expression tag |
Gly 117 | - | expression tag |
Thr 118 | - | expression tag |
Glu 119 | - | expression tag |
Asn 120 | - | expression tag |
Leu 121 | - | expression tag |
Tyr 122 | - | expression tag |
Phe 123 | - | expression tag |
Gln 124 | - | expression tag |
Ser 125 | - | expression tag |
Met 126 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 89106.4 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 432.5 | |
All* | Total formula weight | 89538.9 |