7A4N
Cryo-EM structure of a prefusion stabilized SARS-CoV-2 Spike (D614N, R682S, R685G, A892P, A942P and V987P)(S-closed trimer)
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C | Spike glycoprotein,Fibritin | polymer | 1297 | 142547.3 | 3 | UniProt (P0DTC2) UniProt (P10104) Pfam (PF16451) Pfam (PF09408) Pfam (PF19209) Pfam (PF01601) In PDB | Severe acute respiratory syndrome coronavirus 2 (2019-nCoV) | S glycoprotein,E2,Peplomer protein,Collar protein,Whisker antigen control protein |
2 | D, E, F | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 3 | In PDB GlyTouCan (G42666HT) | |||
3 | A, B, C | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 15 | Chemie (NAG) |
Sequence modifications
A, B, C: 1 - 1208 (UniProt: P0DTC2)
A, B, C: 1211 - 1237 (UniProt: P10104)
PDB | External Database | Details |
---|---|---|
Asn 614 | Asp 614 | engineered mutation |
Ser 682 | Arg 682 | engineered mutation |
Gly 685 | Arg 685 | engineered mutation |
Pro 892 | Ala 892 | engineered mutation |
Pro 942 | Ala 942 | engineered mutation |
Pro 987 | Val 987 | engineered mutation |
Gly 1209 | - | linker |
Ser 1210 | - | linker |
PDB | External Database | Details |
---|---|---|
Leu 1232 | Phe 479 | conflict |
Gly 1238 | - | expression tag |
Arg 1239 | - | expression tag |
Ser 1240 | - | expression tag |
Leu 1241 | - | expression tag |
Glu 1242 | - | expression tag |
Val 1243 | - | expression tag |
Leu 1244 | - | expression tag |
Phe 1245 | - | expression tag |
Gln 1246 | - | expression tag |
Gly 1247 | - | expression tag |
Pro 1248 | - | expression tag |
Gly 1249 | - | expression tag |
Ser 1250 | - | expression tag |
Leu 1251 | - | expression tag |
Pro 1252 | - | expression tag |
Glu 1253 | - | expression tag |
Thr 1254 | - | expression tag |
Gly 1255 | - | expression tag |
Gly 1256 | - | expression tag |
Gly 1257 | - | expression tag |
Ser 1258 | - | expression tag |
Asp 1259 | - | expression tag |
Tyr 1260 | - | expression tag |
Lys 1261 | - | expression tag |
Asp 1262 | - | expression tag |
Asp 1263 | - | expression tag |
Asp 1264 | - | expression tag |
Asp 1265 | - | expression tag |
Lys 1266 | - | expression tag |
Gly 1267 | - | expression tag |
Gly 1268 | - | expression tag |
Gly 1269 | - | expression tag |
Gly 1270 | - | expression tag |
Ser 1271 | - | expression tag |
Gly 1272 | - | expression tag |
Gly 1273 | - | expression tag |
Gly 1274 | - | expression tag |
Gly 1275 | - | expression tag |
Ser 1276 | - | expression tag |
Gly 1277 | - | expression tag |
Gly 1278 | - | expression tag |
Gly 1279 | - | expression tag |
Gly 1280 | - | expression tag |
Ser 1281 | - | expression tag |
Gly 1282 | - | expression tag |
Gly 1283 | - | expression tag |
Gly 1284 | - | expression tag |
Gly 1285 | - | expression tag |
Ser 1286 | - | expression tag |
Gly 1287 | - | expression tag |
Gly 1288 | - | expression tag |
Gly 1289 | - | expression tag |
Gly 1290 | - | expression tag |
Ser 1291 | - | expression tag |
His 1292 | - | expression tag |
His 1293 | - | expression tag |
His 1294 | - | expression tag |
His 1295 | - | expression tag |
His 1296 | - | expression tag |
His 1297 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 3 |
Total formula weight | 427642.0 | |
Branched | Number of molecules | 3 |
Total formula weight | 1273.2 | |
Non-Polymers* | Number of molecules | 15 |
Total formula weight | 3318.1 | |
All* | Total formula weight | 432233.4 |