7A3K
Crystal structure of DPP8 in complex with a b-lactam based inhibitor, A296.1
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (C, A, B) | Dipeptidyl peptidase 8 | polymer | 898 | 103483.4 | 3 | UniProt (Q6V1X1) Pfam (PF19520) Pfam (PF00930) Pfam (PF00326) | Homo sapiens (Human) | DP8,Dipeptidyl peptidase IV-related protein 1,DPRP-1,Dipeptidyl peptidase VIII,DPP VIII,Prolyl dipeptidase DPP8 |
| 2 | D, K, P (C, A, B) | trimethylamine oxide | non-polymer | 75.1 | 3 | Chemie (TMO) | |||
| 3 | E, F, G, H, L... (C, A, B) | CHLORIDE ION | non-polymer | 35.5 | 8 | Chemie (CL) | |||
| 4 | I, N, S (C, A, B) | SODIUM ION | non-polymer | 23.0 | 3 | Chemie (NA) | |||
| 5 | J, O, T (C, A, B) | 1-[3-[[4-[(4-bromophenyl)methyl]piperazin-1-yl]methyl]phenyl]azetidin-2-one | non-polymer | 414.3 | 3 | Chemie (QX8) | |||
| 6 | U, V, W (C, A, B) | water | water | 18.0 | 186 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 310450.1 | |
| Non-Polymers* | Number of molecules | 17 |
| Total formula weight | 1820.9 | |
| All* | Total formula weight | 312271.0 |
