7A3I
Crystal structure of DPP8 in complex with a 4-oxo-b-lactam based inhibitor, LMC375
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (A, B, C) | Dipeptidyl peptidase 8 | polymer | 898 | 103483.4 | 3 | UniProt (Q6V1X1) Pfam (PF19520) Pfam (PF00930) Pfam (PF00326) | Homo sapiens (Human) | DP8,Dipeptidyl peptidase IV-related protein 1,DPRP-1,Dipeptidyl peptidase VIII,DPP VIII,Prolyl dipeptidase DPP8 |
| 2 | D, H, L (A, B, C) | trimethylamine oxide | non-polymer | 75.1 | 3 | Chemie (TMO) | |||
| 3 | E, I, M (A, B, C) | ~{N}-[3,5-bis[[4-[(4-bromophenyl)methyl]piperazin-1-yl]methyl]phenyl]-2-ethyl-2-methanoyl-butanamide | non-polymer | 753.6 | 3 | Chemie (QXH) | |||
| 4 | F, J, N (A, B, C) | SODIUM ION | non-polymer | 23.0 | 3 | Chemie (NA) | |||
| 5 | G, K, O (A, B, C) | CHLORIDE ION | non-polymer | 35.5 | 3 | Chemie (CL) | |||
| 6 | P, Q, R (A, B, C) | water | water | 18.0 | 24 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 310450.1 | |
| Non-Polymers* | Number of molecules | 12 |
| Total formula weight | 2661.5 | |
| All* | Total formula weight | 313111.5 |
