7A32
Crystal structure of the c-Src SH3 domain mutant S94A-T98D-V111L-N113S-T114S at pH 7.0
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Proto-oncogene tyrosine-protein kinase Src | polymer | 60 | 6720.3 | 4 | UniProt (P00523) Pfam (PF00018) | Gallus gallus (Chicken) | Proto-oncogene c-Src,pp60c-src,p60-Src |
| 2 | E, F (B) | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) | |||
| 3 | G (D) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 4 | H, I, J, K (A, B, C, D) | water | water | 18.0 | 342 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 82 - 141 (UniProt: P00523)
| PDB | External Database | Details |
|---|---|---|
| Ala 94 | Ser 94 | engineered mutation |
| Asp 98 | Thr 98 | engineered mutation |
| Leu 111 | Val 111 | engineered mutation |
| Ser 113 | Asn 113 | engineered mutation |
| Ser 114 | Thr 114 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 26881.1 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 284.2 | |
| All* | Total formula weight | 27165.3 |
