7A2Z
Crystal structure of the Fyn SH3 domain L112V-S114N-S115T-E121L-R123H mutant in complex with VSL12 at pH 6.0
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Tyrosine-protein kinase Fyn | polymer | 60 | 6787.4 | 1 | UniProt (P06241) Pfam (PF00018) In PDB | Homo sapiens (Human) | Proto-oncogene Syn,Proto-oncogene c-Fyn,Src-like kinase,SLK,p59-Fyn |
2 | B | VSL12 | polymer | 12 | 1317.6 | 1 | synthetic construct | ||
3 | water | water | 18.0 | 97 | Chemie (HOH) |
Sequence modifications
A: 83 - 142 (UniProt: P06241)
PDB | External Database | Details |
---|---|---|
Val 112 | Leu 112 | engineered mutation |
Asn 114 | Ser 114 | engineered mutation |
Thr 115 | Ser 115 | engineered mutation |
Leu 121 | Glu 121 | engineered mutation |
His 123 | Arg 123 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 8105.0 | |
All* | Total formula weight | 8105.0 |