7A2W
Crystal structure of the Fyn SH3 domain L112V-S114N-S115T-E121L-R123H mutant in complex with VSL12 at pH 3.0
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Tyrosine-protein kinase Fyn | polymer | 61 | 6844.4 | 1 | UniProt (P06241) Pfam (PF00018) | Homo sapiens (Human) | Proto-oncogene Syn,Proto-oncogene c-Fyn,Src-like kinase,SLK,p59-Fyn |
| 2 | B (B) | VSL12 | polymer | 13 | 1343.7 | 1 | synthetic construct | ||
| 3 | C (B) | CITRIC ACID | non-polymer | 192.1 | 1 | Chemie (CIT) | |||
| 4 | D, E (A, B) | water | water | 18.0 | 119 | Chemie (HOH) |
Sequence modifications
A: 83 - 142 (UniProt: P06241)
| PDB | External Database | Details |
|---|---|---|
| Gly 82 | - | expression tag |
| Val 112 | Leu 112 | engineered mutation |
| Asn 114 | Ser 114 | engineered mutation |
| Thr 115 | Ser 115 | engineered mutation |
| Leu 121 | Glu 121 | engineered mutation |
| His 123 | Arg 123 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 8188.1 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 192.1 | |
| All* | Total formula weight | 8380.2 |
