6ZYM
Human C Complex Spliceosome - High-resolution CORE
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (2) | U2 snRNA | polymer | 188 | 60186.4 | 1 | GenBank (36516) | Homo sapiens (Human) | |
| 2 | B (5) | U5 snRNA | polymer | 116 | 36908.7 | 1 | GenBank (36515) | Homo sapiens (Human) | |
| 3 | C (6) | U6 snRNA | polymer | 79 | 25480.2 | 1 | Homo sapiens (Human) | ||
| 4 | D (9) | Corepressor interacting with RBPJ 1 | polymer | 450 | 52441.8 | 1 | UniProt (Q86X95) Pfam (PF10197) | Homo sapiens (Human) | CBF1-interacting corepressor,Recepin |
| 5 | E (A) | Pre-mRNA-processing-splicing factor 8 | polymer | 1755 | 207470.7 | 1 | UniProt (Q6P2Q9) Pfam (PF08082) Pfam (PF08083) Pfam (PF10598) Pfam (PF10597) Pfam (PF10596) | Homo sapiens (Human) | 220 kDa U5 snRNP-specific protein,PRP8 homolog,Splicing factor Prp8,p220 |
| 6 | F (B) | 116 kDa U5 small nuclear ribonucleoprotein component | polymer | 952 | 107225.9 | 1 | UniProt (Q15029) Pfam (PF14492) Pfam (PF03764) Pfam (PF00679) Pfam (PF16004) Pfam (PF00009) Pfam (PF03144) | Homo sapiens (Human) | Elongation factor Tu GTP-binding domain-containing protein 2,SNU114 homolog,hSNU114,U5 snRNP-specific protein,116 kDa,U5-116 kDa |
| 7 | G (C) | SNW domain-containing protein 1 | polymer | 536 | 61610.7 | 1 | UniProt (Q13573) Pfam (PF02731) | Homo sapiens (Human) | Nuclear protein SkiP,Nuclear receptor coactivator NCoA-62,Ski-interacting protein |
| 8 | H (D) | Pleiotropic regulator 1 | polymer | 514 | 57280.8 | 1 | UniProt (O43660) Pfam (PF00400) | Homo sapiens (Human) | |
| 9 | I (E) | Pre-mRNA-processing factor 17 | polymer | 579 | 65612.2 | 1 | UniProt (O60508) Pfam (PF00400) | Homo sapiens (Human) | Cell division cycle 40 homolog,EH-binding protein 3,Ehb3,PRP17 homolog,hPRP17 |
| 10 | J (F) | U5 small nuclear ribonucleoprotein 40 kDa protein | polymer | 357 | 39359.5 | 1 | UniProt (Q96DI7) Pfam (PF00400) | Homo sapiens (Human) | U5-40K,38 kDa-splicing factor,Prp8-binding protein,hPRP8BP,U5 snRNP-specific 40 kDa protein,WD repeat-containing protein 57 |
| 11 | K (L) | Cell division cycle 5-like protein | polymer | 802 | 92406.9 | 1 | UniProt (Q99459) Pfam (PF13921) Pfam (PF11831) | Homo sapiens (Human) | Cdc5-like protein,Pombe cdc5-related protein |
| 12 | L (O) | Crooked neck-like protein 1 | polymer | 848 | 100610.0 | 1 | UniProt (Q9BZJ0) Pfam (PF23231) | Homo sapiens (Human) | Crooked neck homolog,hCrn |
| 13 | M (P) | Pre-mRNA-splicing factor RBM22 | polymer | 218 | 25223.9 | 1 | UniProt (Q9NW64) Pfam (PF21369) Pfam (PF25584) | Homo sapiens (Human) | RNA-binding motif protein 22,Zinc finger CCCH domain-containing protein 16 |
| 14 | N (Q) | Protein BUD31 homolog | polymer | 144 | 17032.8 | 1 | UniProt (P41223) Pfam (PF01125) | Homo sapiens (Human) | Protein EDG-2,Protein G10 homolog |
| 15 | O (R) | Spliceosome-associated protein CWC15 homolog | polymer | 229 | 26674.4 | 1 | UniProt (Q9P013) Pfam (PF04889) | Homo sapiens (Human) | |
| 16 | P (S) | Serine/arginine repetitive matrix protein 2 | polymer | 2752 | 300255.3 | 1 | UniProt (Q9UQ35) Pfam (PF08312) | Homo sapiens (Human) | 300 kDa nuclear matrix antigen,Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa,Ser/Arg-related nuclear matrix protein of 300 kDa,Splicing coactivator subunit SRm300,Tax-responsive enhancer element-binding protein 803,TaxREB803 |
| 17 | Q (T) | Pre-mRNA-splicing factor CWC22 homolog | polymer | 908 | 105646.6 | 1 | UniProt (Q9HCG8) Pfam (PF02854) Pfam (PF02847) | Homo sapiens (Human) | Nucampholin homolog,fSAPb |
| 18 | R (V) | Peptidyl-prolyl cis-trans isomerase-like 1 | polymer | 166 | 18257.8 | 1 | UniProt (Q9Y3C6) Pfam (PF00160) | Homo sapiens (Human) | PPIase,Rotamase PPIL1 |
| 19 | S, T (Y, Z) | pre-mRNA | polymer | 324 | 103979.1 | 2 | Homo sapiens (Human) | ||
| 20 | U (p) | WD repeat-containing protein 70 | polymer | 654 | 73306.2 | 1 | UniProt (Q9NW82) Pfam (PF00400) | Homo sapiens (Human) | |
| 21 | V (r) | Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 | polymer | 1227 | 140720.6 | 1 | UniProt (Q92620) Pfam (PF00270) Pfam (PF00271) Pfam (PF04408) Pfam (PF21010) Pfam (PF07717) | Homo sapiens (Human) | ATP-dependent RNA helicase DHX38,DEAH box protein 38 |
| 22 | W (s) | Pre-mRNA-splicing factor ISY1 homolog | polymer | 285 | 33046.3 | 1 | UniProt (Q9ULR0) Pfam (PF06246) | Homo sapiens (Human) | |
| 23 | X (t) | Pre-mRNA-splicing factor CWC25 homolog | polymer | 425 | 49769.9 | 1 | UniProt (Q9NXE8) Pfam (PF10197) Pfam (PF12542) | Homo sapiens (Human) | Coiled-coil domain-containing protein 49,Spliceosome-associated protein homolog CWC25 |
| 24 | Y (u) | Splicing factor YJU2 | polymer | 178 | 21452.7 | 1 | UniProt (Q9BW85) Pfam (PF04502) | Homo sapiens (Human) | Coiled-coil domain-containing protein 94 |
| 25 | Z (x) | Protein FRG1 | polymer | 258 | 29227.5 | 1 | UniProt (Q14331) Pfam (PF06229) | Homo sapiens (Human) | FSHD region gene 1 protein |
| 26 | AA, BA, CA, DA, EA (6) | MAGNESIUM ION | non-polymer | 24.3 | 5 | Chemie (MG) PubChem (888) | |||
| 27 | FA (A) | INOSITOL HEXAKISPHOSPHATE | non-polymer | 660.0 | 1 | Chemie (IHP) | |||
| 28 | GA (B) | GUANOSINE-5'-TRIPHOSPHATE | non-polymer | 523.2 | 1 | Chemie (GTP) PubChem (177679032) PubChem (135400627) PubChem (135487750) PubChem (136088935) PubChem (136803486) PubChem (135398633) PubChem (135544356) PubChem (135547949) PubChem (135600366) PubChem (135749822) PubChem (136005188) PubChem (136073923) PubChem (136240914) PubChem (136664747) PubChem (136772743) PubChem (136772744) PubChem (136803487) PubChem (137286749) PubChem (164715984) PubChem (171699466) | |||
| 29 | HA, IA, JA, KA, LA... (P, Q, u) | ZINC ION | non-polymer | 65.4 | 7 | Chemie (ZN) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 26 |
| Total formula weight | 1955166.2 | |
| Non-Polymers* | Number of molecules | 14 |
| Total formula weight | 1762.6 | |
| All* | Total formula weight | 1956928.8 |
