6ZYM
Human C Complex Spliceosome - High-resolution CORE
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (2) | U2 snRNA | polymer | 188 | 60186.4 | 1 | GenBank (36516) | Homo sapiens (Human) | |
| 2 | B (5) | U5 snRNA | polymer | 116 | 36908.7 | 1 | GenBank (36515) | Homo sapiens (Human) | |
| 3 | C (6) | U6 snRNA | polymer | 79 | 25480.2 | 1 | Homo sapiens (Human) | ||
| 4 | D (9) | Corepressor interacting with RBPJ 1 | polymer | 450 | 52441.8 | 1 | UniProt (Q86X95) Pfam (PF10197) | Homo sapiens (Human) | CBF1-interacting corepressor,Recepin |
| 5 | E (A) | Pre-mRNA-processing-splicing factor 8 | polymer | 1755 | 207470.7 | 1 | UniProt (Q6P2Q9) Pfam (PF08082) Pfam (PF08083) Pfam (PF10598) Pfam (PF10597) Pfam (PF10596) | Homo sapiens (Human) | 220 kDa U5 snRNP-specific protein,PRP8 homolog,Splicing factor Prp8,p220 |
| 6 | F (B) | 116 kDa U5 small nuclear ribonucleoprotein component | polymer | 952 | 107225.9 | 1 | UniProt (Q15029) Pfam (PF14492) Pfam (PF03764) Pfam (PF00679) Pfam (PF16004) Pfam (PF00009) Pfam (PF03144) | Homo sapiens (Human) | Elongation factor Tu GTP-binding domain-containing protein 2,SNU114 homolog,hSNU114,U5 snRNP-specific protein,116 kDa,U5-116 kDa |
| 7 | G (C) | SNW domain-containing protein 1 | polymer | 536 | 61610.7 | 1 | UniProt (Q13573) Pfam (PF02731) | Homo sapiens (Human) | Nuclear protein SkiP,Nuclear receptor coactivator NCoA-62,Ski-interacting protein |
| 8 | H (D) | Pleiotropic regulator 1 | polymer | 514 | 57280.8 | 1 | UniProt (O43660) Pfam (PF00400) | Homo sapiens (Human) | |
| 9 | I (E) | Pre-mRNA-processing factor 17 | polymer | 579 | 65612.2 | 1 | UniProt (O60508) Pfam (PF00400) | Homo sapiens (Human) | Cell division cycle 40 homolog,EH-binding protein 3,Ehb3,PRP17 homolog,hPRP17 |
| 10 | J (F) | U5 small nuclear ribonucleoprotein 40 kDa protein | polymer | 357 | 39359.5 | 1 | UniProt (Q96DI7) Pfam (PF00400) | Homo sapiens (Human) | U5-40K,38 kDa-splicing factor,Prp8-binding protein,hPRP8BP,U5 snRNP-specific 40 kDa protein,WD repeat-containing protein 57 |
| 11 | K (L) | Cell division cycle 5-like protein | polymer | 802 | 92406.9 | 1 | UniProt (Q99459) Pfam (PF13921) Pfam (PF11831) | Homo sapiens (Human) | Cdc5-like protein,Pombe cdc5-related protein |
| 12 | L (O) | Crooked neck-like protein 1 | polymer | 848 | 100610.0 | 1 | UniProt (Q9BZJ0) Pfam (PF02184) | Homo sapiens (Human) | Crooked neck homolog,hCrn |
| 13 | M (P) | Pre-mRNA-splicing factor RBM22 | polymer | 218 | 25223.9 | 1 | UniProt (Q9NW64) Pfam (PF21369) | Homo sapiens (Human) | RNA-binding motif protein 22,Zinc finger CCCH domain-containing protein 16 |
| 14 | N (Q) | Protein BUD31 homolog | polymer | 144 | 17032.8 | 1 | UniProt (P41223) Pfam (PF01125) | Homo sapiens (Human) | Protein EDG-2,Protein G10 homolog |
| 15 | O (R) | Spliceosome-associated protein CWC15 homolog | polymer | 229 | 26674.4 | 1 | UniProt (Q9P013) Pfam (PF04889) | Homo sapiens (Human) | |
| 16 | P (S) | Serine/arginine repetitive matrix protein 2 | polymer | 2752 | 300255.3 | 1 | UniProt (Q9UQ35) Pfam (PF08312) | Homo sapiens (Human) | 300 kDa nuclear matrix antigen,Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa,Ser/Arg-related nuclear matrix protein of 300 kDa,Splicing coactivator subunit SRm300,Tax-responsive enhancer element-binding protein 803,TaxREB803 |
| 17 | Q (T) | Pre-mRNA-splicing factor CWC22 homolog | polymer | 908 | 105646.6 | 1 | UniProt (Q9HCG8) Pfam (PF02854) Pfam (PF02847) | Homo sapiens (Human) | Nucampholin homolog,fSAPb |
| 18 | R (V) | Peptidyl-prolyl cis-trans isomerase-like 1 | polymer | 166 | 18257.8 | 1 | UniProt (Q9Y3C6) Pfam (PF00160) | Homo sapiens (Human) | PPIase,Rotamase PPIL1 |
| 19 | S, T (Y, Z) | pre-mRNA | polymer | 324 | 103979.1 | 2 | Homo sapiens (Human) | ||
| 20 | U (p) | WD repeat-containing protein 70 | polymer | 654 | 73306.2 | 1 | UniProt (Q9NW82) Pfam (PF00400) | Homo sapiens (Human) | |
| 21 | V (r) | Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 | polymer | 1227 | 140720.6 | 1 | UniProt (Q92620) Pfam (PF00270) Pfam (PF00271) Pfam (PF04408) Pfam (PF21010) Pfam (PF07717) | Homo sapiens (Human) | ATP-dependent RNA helicase DHX38,DEAH box protein 38 |
| 22 | W (s) | Pre-mRNA-splicing factor ISY1 homolog | polymer | 285 | 33046.3 | 1 | UniProt (Q9ULR0) Pfam (PF06246) | Homo sapiens (Human) | |
| 23 | X (t) | Pre-mRNA-splicing factor CWC25 homolog | polymer | 425 | 49769.9 | 1 | UniProt (Q9NXE8) Pfam (PF10197) Pfam (PF12542) | Homo sapiens (Human) | Coiled-coil domain-containing protein 49,Spliceosome-associated protein homolog CWC25 |
| 24 | Y (u) | Splicing factor YJU2 | polymer | 178 | 21452.7 | 1 | UniProt (Q9BW85) Pfam (PF04502) | Homo sapiens (Human) | Coiled-coil domain-containing protein 94 |
| 25 | Z (x) | Protein FRG1 | polymer | 258 | 29227.5 | 1 | UniProt (Q14331) Pfam (PF06229) | Homo sapiens (Human) | FSHD region gene 1 protein |
| 26 | AA, BA, CA, DA, EA (6) | MAGNESIUM ION | non-polymer | 24.3 | 5 | Chemie (MG) | |||
| 27 | FA (A) | INOSITOL HEXAKISPHOSPHATE | non-polymer | 660.0 | 1 | Chemie (IHP) | |||
| 28 | GA (B) | GUANOSINE-5'-TRIPHOSPHATE | non-polymer | 523.2 | 1 | Chemie (GTP) | |||
| 29 | HA, IA, JA, KA, LA... (P, Q, u) | ZINC ION | non-polymer | 65.4 | 7 | Chemie (ZN) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 26 |
| Total formula weight | 1955166.2 | |
| Non-Polymers* | Number of molecules | 14 |
| Total formula weight | 1762.6 | |
| All* | Total formula weight | 1956928.8 |
