6ZYF

Notum_Ghrelin complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Palmitoleoyl-protein carboxylesterase NOTUM	polymer	383	43551.1	2	UniProt (Q6P988) Pfam (PF03283)	Homo sapiens (Human)	hNOTUM
2	C, E (A, B)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	2	Chemie (NAG)
3	D, F (A, B)	[(2~{S})-2-azanyl-3-oxidanylidene-propyl] octanoate	non-polymer		215.3	2	Chemie (K4Q)
4	G, H (B)	1,2-ETHANEDIOL	non-polymer		62.1	2	Chemie (EDO)
5	I, J (A, B)	water	water		18.0	56	Chemie (HOH)

Sequence modifications

A, B: 81 - 451 (UniProt: Q6P988)

PDB	External Database	Details
Glu 78	-	expression tag
Thr 79	-	expression tag
Gly 80	-	expression tag
Ala 232	Ser 232	conflict
Ser 330	Cys 330	conflict
Gly 452	-	expression tag
Thr 453	-	expression tag
Lys 454	-	expression tag
His 455	-	expression tag
His 456	-	expression tag
His 457	-	expression tag
His 458	-	expression tag
His 459	-	expression tag
His 460	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	87102.3
Non-Polymers*	Number of molecules	6
	Total formula weight	997.1
All*	Total formula weight	88099.4

*Water molecules are not included.