6ZWM

cryo-EM structure of human mTOR complex 2, overall refinement

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Serine/threonine-protein kinase mTOR	polymer	2549	289258.0	2	UniProt (P42345) Pfam (PF11865) Pfam (PF02259) Pfam (PF08771) Pfam (PF00454) Pfam (PF02260)	Homo sapiens (Human)	FK506-binding protein 12-rapamycin complex-associated protein 1,FKBP12-rapamycin complex-associated protein,Mammalian target of rapamycin,mTOR,Mechanistic target of rapamycin,Rapamycin and FKBP12 target 1,Rapamycin target protein 1
2	C, D (C, D)	Target of rapamycin complex subunit LST8	polymer	326	35910.1	2	UniProt (Q9BVC4) Pfam (PF00400)	Homo sapiens (Human)	TORC subunit LST8,G protein beta subunit-like,Protein GbetaL,Mammalian lethal with SEC13 protein 8,mLST8
3	E, F (E, F)	Rapamycin-insensitive companion of mTOR	polymer	1708	192472.9	2	UniProt (Q6R327) Pfam (PF14664) Pfam (PF14666) Pfam (PF14663) Pfam (PF14668) Pfam (PF14665)	Homo sapiens (Human)	AVO3 homolog,hAVO3
4	G, H (G, H)	Target of rapamycin complex 2 subunit MAPKAP1	polymer	522	59206.7	2	UniProt (Q9BPZ7) Pfam (PF05422) Pfam (PF16978) Pfam (PF16979)	Homo sapiens (Human)	TORC2 subunit MAPKAP1,Mitogen-activated protein kinase 2-associated protein 1,Stress-activated map kinase-interacting protein 1,mSIN1
5	I, K, N, P (A, B, E, F)	PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER	non-polymer		523.2	4	Chemie (AGS)
6	J, L (A, B)	INOSITOL HEXAKISPHOSPHATE	non-polymer		660.0	2	Chemie (IHP)
7	M, O (E, F)	ZINC ION	non-polymer		65.4	2	Chemie (ZN)
8	Q, R (G, H)	ACETYL GROUP	non-polymer		44.1	2	Chemie (ACE)

Contents of the asymmetric unit

Polymers	Number of chains	8
	Total formula weight	1153695.4
Non-Polymers*	Number of molecules	10
	Total formula weight	3632.0
All*	Total formula weight	1157327.4

*Water molecules are not included.