6ZWM
cryo-EM structure of human mTOR complex 2, overall refinement
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Serine/threonine-protein kinase mTOR | polymer | 2549 | 289258.0 | 2 | UniProt (P42345) Pfam (PF11865) Pfam (PF02259) Pfam (PF08771) Pfam (PF00454) Pfam (PF02260) In PDB | Homo sapiens (Human) | FK506-binding protein 12-rapamycin complex-associated protein 1,FKBP12-rapamycin complex-associated protein,Mammalian target of rapamycin,mTOR,Mechanistic target of rapamycin,Rapamycin and FKBP12 target 1,Rapamycin target protein 1 |
2 | C, D | Target of rapamycin complex subunit LST8 | polymer | 326 | 35910.1 | 2 | UniProt (Q9BVC4) Pfam (PF00400) In PDB | Homo sapiens (Human) | TORC subunit LST8,G protein beta subunit-like,Protein GbetaL,Mammalian lethal with SEC13 protein 8,mLST8 |
3 | E, F | Rapamycin-insensitive companion of mTOR | polymer | 1708 | 192472.9 | 2 | UniProt (Q6R327) Pfam (PF14664) Pfam (PF14666) Pfam (PF14663) Pfam (PF14668) Pfam (PF14665) In PDB | Homo sapiens (Human) | AVO3 homolog,hAVO3 |
4 | G, H | Target of rapamycin complex 2 subunit MAPKAP1 | polymer | 522 | 59206.7 | 2 | UniProt (Q9BPZ7) Pfam (PF05422) Pfam (PF16978) Pfam (PF16979) In PDB | Homo sapiens (Human) | TORC2 subunit MAPKAP1,Mitogen-activated protein kinase 2-associated protein 1,Stress-activated map kinase-interacting protein 1,mSIN1 |
5 | A, B, E, F | PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER | non-polymer | 523.2 | 4 | Chemie (AGS) | |||
6 | A, B | INOSITOL HEXAKISPHOSPHATE | non-polymer | 660.0 | 2 | Chemie (IHP) | |||
7 | E, F | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
8 | G, H | ACETYL GROUP | non-polymer | 44.1 | 2 | Chemie (ACE) |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 8 |
Total formula weight | 1153695.4 | |
Non-Polymers* | Number of molecules | 10 |
Total formula weight | 3632.0 | |
All* | Total formula weight | 1157327.4 |