6ZVJ
Structure of a human ABCE1-bound 43S pre-initiation complex - State II
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (a) | 40S ribosomal protein SA | polymer | 216 | 24260.8 | 1 | UniProt (P08865) Pfam (PF00318) | Homo sapiens (Human) | 37 kDa laminin receptor precursor,37LRP,37/67 kDa laminin receptor,LRP/LR,67 kDa laminin receptor,67LR,Colon carcinoma laminin-binding protein,Laminin receptor 1,LamR,Laminin-binding protein precursor p40,LBP/p40,Multidrug resistance-associated protein MGr1-Ag,NEM/1CHD4,Small ribosomal subunit protein uS2 |
| 2 | B (p) | 40S ribosomal protein S3a | polymer | 211 | 24560.9 | 1 | UniProt (P61247) Pfam (PF01015) | Homo sapiens (Human) | Small ribosomal subunit protein eS1,v-fos transformation effector protein,Fte-1 |
| 3 | C (d) | 40S ribosomal protein S2 | polymer | 216 | 23861.2 | 1 | UniProt (P15880) Pfam (PF00333) Pfam (PF03719) | Homo sapiens (Human) | 40S ribosomal protein S4,Protein LLRep3,Small ribosomal subunit protein uS5 |
| 4 | D (Q) | 40S ribosomal protein S26 | polymer | 101 | 11645.8 | 1 | UniProt (P62854) Pfam (PF01283) | Homo sapiens (Human) | Small ribosomal subunit protein eS26 |
| 5 | E (q) | 40S ribosomal protein S4, X isoform | polymer | 255 | 28893.0 | 1 | UniProt (P62701) Pfam (PF08071) Pfam (PF00900) Pfam (PF00467) Pfam (PF16121) | Homo sapiens (Human) | SCR10,Single copy abundant mRNA protein,Small ribosomal subunit protein eS4 |
| 6 | F (W) | 60S ribosomal protein L41 | polymer | 24 | 3344.3 | 1 | UniProt (P62945) Pfam (PF05162) | Homo sapiens (Human) | HG12,Large ribosomal subunit protein eL41 |
| 7 | G (r) | 40S ribosomal protein S6 | polymer | 222 | 25612.3 | 1 | UniProt (P62753) Pfam (PF01092) | Homo sapiens (Human) | Phosphoprotein NP33,Small ribosomal subunit protein eS6 |
| 8 | H (s) | 40S ribosomal protein S7 | polymer | 181 | 20788.3 | 1 | UniProt (P62081) Pfam (PF01251) | Homo sapiens (Human) | Small ribosomal subunit protein eS7 |
| 9 | I (t) | 40S ribosomal protein S8 | polymer | 205 | 23946.0 | 1 | UniProt (P62241) Pfam (PF01201) | Homo sapiens (Human) | Small ribosomal subunit protein eS8 |
| 10 | J (c) | 40S ribosomal protein S9 | polymer | 180 | 21279.3 | 1 | UniProt (P46781) Pfam (PF00163) Pfam (PF01479) | Homo sapiens (Human) | Small ribosomal subunit protein uS4 |
| 11 | K (n) | 40S ribosomal protein S11 | polymer | 144 | 16913.0 | 1 | UniProt (P62280) Pfam (PF16205) Pfam (PF00366) | Homo sapiens (Human) | Small ribosomal subunit protein uS17 |
| 12 | L (m) | 40S ribosomal protein S13 | polymer | 149 | 17057.1 | 1 | UniProt (P62277) Pfam (PF08069) Pfam (PF00312) | Homo sapiens (Human) | Small ribosomal subunit protein uS15 |
| 13 | M (i) | 40S ribosomal protein S14 | polymer | 125 | 13463.5 | 1 | UniProt (A0A2R8Y811) Pfam (PF00411) | Homo sapiens (Human) | |
| 14 | N (y) | 40S ribosomal protein S21 | polymer | 82 | 8977.2 | 1 | UniProt (P63220) Pfam (PF01249) | Homo sapiens (Human) | Small ribosomal subunit protein eS21 |
| 15 | O (f) | 40S ribosomal protein S15a | polymer | 129 | 14734.4 | 1 | UniProt (P62244) Pfam (PF00410) | Homo sapiens (Human) | Small ribosomal subunit protein uS8 |
| 16 | P (j) | 40S ribosomal protein S23 | polymer | 139 | 15372.1 | 1 | UniProt (P62266) Pfam (PF00164) | Homo sapiens (Human) | Small ribosomal subunit protein uS12 |
| 17 | Q (z) | 40S ribosomal protein S24 | polymer | 122 | 14259.9 | 1 | UniProt (E7ETK0) Pfam (PF01282) | Homo sapiens (Human) | |
| 18 | R (R) | 40S ribosomal protein S27 | polymer | 82 | 9210.8 | 1 | UniProt (P42677) Pfam (PF01667) | Homo sapiens (Human) | Metallopan-stimulin 1,MPS-1,Small ribosomal subunit protein eS27 |
| 19 | S (T) | 40S ribosomal protein S30 | polymer | 44 | 5069.0 | 1 | UniProt (P62861) Pfam (PF04758) | Homo sapiens (Human) | Small ribosomal subunit protein eS30 |
| 20 | T (2) | 18S ribosomal RNA | polymer | 1720 | 555210.7 | 1 | Homo sapiens (Human) | ||
| 21 | U (w) | 40S ribosomal protein S17 | polymer | 130 | 15036.5 | 1 | UniProt (P08708) Pfam (PF00833) | Homo sapiens (Human) | Small ribosomal subunit protein eS17 |
| 22 | V (g) | 40S ribosomal protein S16 | polymer | 138 | 15637.4 | 1 | UniProt (P62249) Pfam (PF00380) | Homo sapiens (Human) | Small ribosomal subunit protein uS9 |
| 23 | W (b) | 40S ribosomal protein S3 | polymer | 224 | 24871.2 | 1 | UniProt (P23396) Pfam (PF07650) Pfam (PF00189) | Homo sapiens (Human) | Small ribosomal subunit protein uS3 |
| 24 | X (e) | 40S ribosomal protein S5 | polymer | 189 | 21327.7 | 1 | UniProt (P46782) Pfam (PF00177) | Homo sapiens (Human) | Small ribosomal subunit protein uS7 |
| 25 | Y (u) | 40S ribosomal protein S10 | polymer | 95 | 11372.5 | 1 | UniProt (P46783) Pfam (PF03501) | Homo sapiens (Human) | Small ribosomal subunit protein eS10 |
| 26 | Z (v) | 40S ribosomal protein S12 | polymer | 116 | 12945.1 | 1 | UniProt (P25398) Pfam (PF01248) | Homo sapiens (Human) | Small ribosomal subunit protein eS12 |
| 27 | AA (o) | 40S ribosomal protein S15 | polymer | 119 | 14010.5 | 1 | UniProt (P62841) Pfam (PF00203) | Homo sapiens (Human) | RIG protein,Small ribosomal subunit protein uS19 |
| 28 | BA (k) | 40S ribosomal protein S18 | polymer | 140 | 16496.2 | 1 | UniProt (P62269) Pfam (PF00416) | Homo sapiens (Human) | Ke-3,Ke3,Small ribosomal subunit protein uS13 |
| 29 | CA (x) | 40S ribosomal protein S19 | polymer | 141 | 15563.9 | 1 | UniProt (P39019) Pfam (PF01090) | Homo sapiens (Human) | Small ribosomal subunit protein eS19 |
| 30 | DA (h) | 40S ribosomal protein S20 | polymer | 98 | 11186.3 | 1 | UniProt (P60866) Pfam (PF00338) | Homo sapiens (Human) | Small ribosomal subunit protein uS10 |
| 31 | EA (P) | 40S ribosomal protein S25 | polymer | 70 | 7938.4 | 1 | UniProt (P62851) Pfam (PF03297) | Homo sapiens (Human) | Small ribosomal subunit protein eS25 |
| 32 | FA (S) | 40S ribosomal protein S28 | polymer | 61 | 6878.9 | 1 | UniProt (P62857) Pfam (PF01200) | Homo sapiens (Human) | Small ribosomal subunit protein eS28 |
| 33 | GA (l) | 40S ribosomal protein S29 | polymer | 54 | 6444.5 | 1 | UniProt (P62273) Pfam (PF00253) | Homo sapiens (Human) | Small ribosomal subunit protein uS14 |
| 34 | HA (U) | Ubiquitin-40S ribosomal protein S27a | polymer | 62 | 7257.6 | 1 | UniProt (P62979) Pfam (PF01599) | Homo sapiens (Human) | Ubiquitin carboxyl extension protein 80 |
| 35 | IA (V) | Receptor of activated protein C kinase 1 | polymer | 309 | 34224.6 | 1 | UniProt (P63244) Pfam (PF00400) | Homo sapiens (Human) | Cell proliferation-inducing gene 21 protein,Guanine nucleotide-binding protein subunit beta-2-like 1,Guanine nucleotide-binding protein subunit beta-like protein 12.3,Human lung cancer oncogene 7 protein,HLC-7,Receptor for activated C kinase,Small ribosomal subunit protein RACK1 |
| 36 | JA (I) | Eukaryotic translation initiation factor 3 subunit I | polymer | 316 | 35352.5 | 1 | UniProt (Q13347) Pfam (PF00400) Pfam (PF12894) | Homo sapiens (Human) | eIF3i,Eukaryotic translation initiation factor 3 subunit 2,TGF-beta receptor-interacting protein 1,TRIP-1,eIF-3-beta,eIF3 p36 |
| 37 | KA (B) | Eukaryotic translation initiation factor 3 subunit B | polymer | 566 | 65902.0 | 1 | UniProt (P55884) Pfam (PF00076) Pfam (PF08662) | Homo sapiens (Human) | eIF3b,Eukaryotic translation initiation factor 3 subunit 9,Prt1 homolog,hPrt1,eIF-3-eta,eIF3 p110,eIF3 p116 |
| 38 | LA (A) | Eukaryotic translation initiation factor 3 subunit A | polymer | 722 | 85564.2 | 1 | UniProt (Q14152) Pfam (PF22591) Pfam (PF01399) | Homo sapiens (Human) | eIF3a,Eukaryotic translation initiation factor 3 subunit 10,eIF-3-theta,eIF3 p167,eIF3 p180,eIF3 p185 |
| 39 | MA (C) | Eukaryotic translation initiation factor 3 subunit C | polymer | 743 | 86197.6 | 1 | UniProt (B4DVU3) Pfam (PF05470) Pfam (PF01399) | Homo sapiens (Human) | eIF3c,Eukaryotic translation initiation factor 3 subunit 8,eIF3 p110 |
| 40 | NA (E) | Eukaryotic translation initiation factor 3 subunit E | polymer | 429 | 50438.7 | 1 | UniProt (P60228) Pfam (PF09440) Pfam (PF01399) Pfam (PF21357) | Homo sapiens (Human) | eIF3e,Eukaryotic translation initiation factor 3 subunit 6,Viral integration site protein INT-6 homolog,eIF-3 p48 |
| 41 | OA (F) | Eukaryotic translation initiation factor 3 subunit F | polymer | 269 | 29836.0 | 1 | UniProt (O00303) Pfam (PF01398) Pfam (PF13012) | Homo sapiens (Human) | eIF3f,Deubiquitinating enzyme eIF3f,Eukaryotic translation initiation factor 3 subunit 5,eIF-3-epsilon,eIF3 p47 |
| 42 | PA (H) | Eukaryotic translation initiation factor 3 subunit H | polymer | 318 | 36960.1 | 1 | UniProt (O15372) Pfam (PF01398) Pfam (PF19445) | Homo sapiens (Human) | eIF3h,Eukaryotic translation initiation factor 3 subunit 3,eIF-3-gamma,eIF3 p40 subunit |
| 43 | QA (K) | Eukaryotic translation initiation factor 3 subunit K | polymer | 217 | 24952.4 | 1 | UniProt (Q9UBQ5) Pfam (PF10075) | Homo sapiens (Human) | eIF3k,Eukaryotic translation initiation factor 3 subunit 12,Muscle-specific gene M9 protein,PLAC-24,eIF-3 p25,eIF-3 p28 |
| 44 | RA (L) | Eukaryotic translation initiation factor 3 subunit L | polymer | 372 | 44172.7 | 1 | UniProt (Q9Y262) Pfam (PF10255) | Homo sapiens (Human) | eIF3l,Eukaryotic translation initiation factor 3 subunit 6-interacting protein,Eukaryotic translation initiation factor 3 subunit E-interacting protein |
| 45 | SA (M) | Eukaryotic translation initiation factor 3 subunit M | polymer | 362 | 41278.4 | 1 | UniProt (Q7L2H7) Pfam (PF01399) Pfam (PF18005) | Homo sapiens (Human) | eIF3m,Fetal lung protein B5,hFL-B5,PCI domain-containing protein 1 |
| 46 | TA (1) | ATP-binding cassette sub-family E member 1 | polymer | 595 | 66972.8 | 1 | UniProt (P61221) Pfam (PF04068) Pfam (PF00037) Pfam (PF00005) | Homo sapiens (Human) | 2'-5'-oligoadenylate-binding protein,HuHP68,RNase L inhibitor,Ribonuclease 4 inhibitor,RNS4I |
| 47 | UA (N) | Eukaryotic translation initiation factor 1 | polymer | 91 | 10388.9 | 1 | UniProt (P41567) Pfam (PF01253) | Homo sapiens (Human) | eIF1,A121,Protein translation factor SUI1 homolog,Sui1iso1 |
| 48 | VA (D) | Eukaryotic translation initiation factor 3 subunit D | polymer | 527 | 61489.4 | 1 | UniProt (O15371) Pfam (PF05091) | Homo sapiens (Human) | eIF3d,Eukaryotic translation initiation factor 3 subunit 7,eIF-3-zeta,eIF3 p66 |
| 49 | WA (Y) | RNA recognition motif (unknown) | polymer | 78 | 5562.1 | 1 | Homo sapiens (Human) | ||
| 50 | XA, YA (G, J) | Eukaryotic translation initiation factor 3 subunit J | polymer | 258 | 29108.5 | 2 | UniProt (O75822) Pfam (PF08597) | Homo sapiens (Human) | eIF3j,Eukaryotic translation initiation factor 3 subunit 1,eIF-3-alpha,eIF3 p35 |
| 51 | AB, BB, ZA (l, U, Q) | ZINC ION | non-polymer | 65.4 | 3 | Chemie (ZN) | |||
| 52 | CB, DB (1) | IRON/SULFUR CLUSTER | non-polymer | 351.6 | 2 | Chemie (SF4) | |||
| 53 | EB (1) | ADENOSINE-5'-DIPHOSPHATE | non-polymer | 427.2 | 1 | Chemie (ADP) | |||
| 54 | FB, HB (1) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 55 | GB (1) | ADENOSINE-5'-TRIPHOSPHATE | non-polymer | 507.2 | 1 | Chemie (ATP) |
Sequence modifications
s: 8 - 193 (UniProt: P62081)
T: 7 - 58 (UniProt: P62861)
C: 1 - 913 (UniProt: B4DVU3)
| PDB | External Database | Details |
|---|---|---|
| Ile 8 | Gly 13 | conflict |
| Val 9 | Glu 14 | conflict |
| Asn 12 | Asp 17 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Gly 54 | Val 46 | conflict |
| Asn 56 | Thr 48 | conflict |
| Ala 57 | Phe 49 | conflict |
| Asn 58 | Gly 50 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Met 130 | - | insertion |
| Asn 131 | His 130 | conflict |
| Lys 132 | Asp 131 | conflict |
| Asn 133 | Arg 132 | conflict |
| Asn 134 | Lys 133 | conflict |
| Ala 135 | Ser 134 | conflict |
| Ala 137 | Arg 136 | conflict |
| - | Asp 138 | deletion |
| - | Glu 139 | deletion |
| - | Glu 140 | deletion |
| - | Glu 141 | deletion |
| - | Glu 142 | deletion |
| - | Asp 143 | deletion |
| - | Asn 144 | deletion |
| - | Glu 145 | deletion |
| - | Gly 146 | deletion |
| - | Gly 147 | deletion |
| - | Glu 148 | deletion |
| - | Trp 149 | deletion |
| - | Glu 150 | deletion |
| - | Arg 151 | deletion |
| - | Val 152 | deletion |
| - | Arg 153 | deletion |
| - | Gly 154 | deletion |
| - | Gly 155 | deletion |
| - | Val 156 | deletion |
| Ser 139 | Pro 157 | conflict |
| Thr 140 | Leu 158 | conflict |
| Leu 141 | Val 159 | conflict |
| Arg 142 | Lys 160 | conflict |
| Gln 143 | Glu 161 | conflict |
| Ile 145 | Pro 163 | conflict |
| Arg 146 | Lys 164 | conflict |
| Lys 147 | Met 165 | conflict |
| Tyr 148 | Phe 166 | conflict |
| Asn 149 | Ala 167 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 51 |
| Total formula weight | 1802935.6 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 1882.5 | |
| All* | Total formula weight | 1804818.1 |
