6ZPT
Crystal structure of the open conformation of S2_S'-mutant human Angiotensin-1 converting enzyme N-domain.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D | Angiotensin-converting enzyme | polymer | 629 | 72544.5 | 4 | UniProt (P12821) Pfam (PF01401) In PDB | Homo sapiens (Human) | ACE,Dipeptidyl carboxypeptidase I,Kininase II |
| 2 | E | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 1 | In PDB GlyTouCan (G42666HT) | |||
| 3 | F, G, H | alpha-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 367.3 | 3 | In PDB GlyTouCan (G86851RC) | |||
| 4 | C, D, A, B | BICINE | non-polymer | 163.2 | 4 | Chemie (BCN) | |||
| 5 | A, B | 2-(2-METHOXYETHOXY)ETHANOL | non-polymer | 120.1 | 3 | Chemie (PG0) | |||
| 6 | C, D, A, B | ZINC ION | non-polymer | 65.4 | 4 | Chemie (ZN) | |||
| 7 | C, D, A, B | CHLORIDE ION | non-polymer | 35.5 | 4 | Chemie (CL) | |||
| 8 | C, D, A, B | CALCIUM ION | non-polymer | 40.1 | 4 | Chemie (CA) | |||
| 9 | B, C | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 3 | Chemie (NAG) | |||
| 10 | C, D, B | 1,2-ETHANEDIOL | non-polymer | 62.1 | 8 | Chemie (EDO) | |||
| 11 | water | water | 18.0 | 55 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 1 - 628 (UniProt: P12821)
| PDB | External Database | Details |
|---|---|---|
| Gln 9 | Asn 38 | engineered mutation |
| Gln 25 | Asn 54 | engineered mutation |
| Gln 82 | Asn 111 | engineered mutation |
| Gln 117 | Asn 146 | engineered mutation |
| Gln 131 | Asn 160 | engineered mutation |
| Thr 260 | Ser 289 | engineered mutation |
| Ser 262 | Glu 291 | engineered mutation |
| Gln 289 | Asn 318 | engineered mutation |
| Glu 354 | Asp 383 | engineered mutation |
| Val 357 | Ser 386 | engineered mutation |
| Val 358 | Thr 387 | engineered mutation |
| Phe 369 | Tyr 398 | engineered mutation |
| Glu 381 | Arg 410 | engineered mutation |
| Asp 431 | Glu 460 | engineered mutation |
| Arg 545 | Gln 574 | engineered mutation |
| Leu 576 | Pro 605 | engineered mutation |
| Leu 629 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 290177.9 | |
| Branched | Number of molecules | 4 |
| Total formula weight | 1526.4 | |
| Non-Polymers* | Number of molecules | 30 |
| Total formula weight | 2737.1 | |
| All* | Total formula weight | 294441.4 |
