6ZPQ
Crystal structure of the open conformation of Angiotensin-1 converting enzyme N-domain.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Angiotensin-converting enzyme | polymer | 629 | 72606.5 | 4 | UniProt (P12821) Pfam (PF01401) | Homo sapiens (Human) | ACE,Dipeptidyl carboxypeptidase I,Kininase II |
| 2 | E, H, J (E, H, J) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 3 | In PDB GlyTouCan (G42666HT) | |||
| 3 | F, G, I, K (F, G, I, K) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 570.5 | 4 | In PDB GlyTouCan (G21290RB) | |||
| 4 | CB, DA, JB, KB, L... (D, B, A, C) | BORIC ACID | non-polymer | 61.8 | 8 | Chemie (BO3) | |||
| 5 | DB, EA, M, O, SA (D, B, A, C) | BICINE | non-polymer | 163.2 | 5 | Chemie (BCN) | |||
| 6 | FA, LA, MA, P (B, A) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 4 | Chemie (PEG) | |||
| 7 | FB, GB, HB, IA, IB... (D, B, A, C) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 14 | Chemie (EDO) | |||
| 8 | EB, GA, HA, R, V (D, B, A) | TRIETHYLENE GLYCOL | non-polymer | 150.2 | 5 | Chemie (PGE) | |||
| 9 | LB, NA, Y, YA (D, B, A, C) | ZINC ION | non-polymer | 65.4 | 4 | Chemie (ZN) | |||
| 10 | MB, OA, Z, ZA (D, B, A, C) | CHLORIDE ION | non-polymer | 35.5 | 4 | Chemie (CL) | |||
| 11 | AA, AB, PA (A, C, B) | MAGNESIUM ION | non-polymer | 24.3 | 3 | Chemie (MG) | |||
| 12 | BA, BB, NB, QA (A, C, D, B) | CALCIUM ION | non-polymer | 40.1 | 4 | Chemie (CA) | |||
| 13 | CA (B) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 1 | Chemie (NAG) | |||
| 14 | KA, TA (B, C) | 2-METHOXYETHANOL | non-polymer | 76.1 | 2 | Chemie (MXE) | |||
| 15 | RA (B) | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) | |||
| 16 | OB, PB, QB, RB (A, B, C, D) | water | water | 18.0 | 1670 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 1 - 628 (UniProt: P12821)
| PDB | External Database | Details |
|---|---|---|
| Gln 9 | Asn 38 | engineered mutation |
| Gln 25 | Asn 54 | engineered mutation |
| Gln 82 | Asn 111 | engineered mutation |
| Gln 117 | Asn 146 | engineered mutation |
| Gln 131 | Asn 160 | engineered mutation |
| Gln 289 | Asn 318 | engineered mutation |
| Arg 545 | Gln 574 | engineered mutation |
| Leu 576 | Pro 605 | engineered mutation |
| Leu 629 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 290426.0 | |
| Branched | Number of molecules | 7 |
| Total formula weight | 3555.4 | |
| Non-Polymers* | Number of molecules | 55 |
| Total formula weight | 4387.9 | |
| All* | Total formula weight | 298369.3 |
