6ZOG
Minocycline binding to the deep binding pocket of AcrB-I38F_I671T
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (A, B, C) | Multidrug efflux pump subunit AcrB | polymer | 1057 | 114758.3 | 3 | UniProt (P31224) Pfam (PF00873) | Escherichia coli K-12 | AcrAB-TolC multidrug efflux pump subunit AcrB,Acridine resistance protein B |
| 2 | D, E (D, E) | DARPIN | polymer | 169 | 18317.6 | 2 | synthetic construct | ||
| 3 | F, H, J, K, L... (A, B, C) | DODECYL-BETA-D-MALTOSIDE | non-polymer | 510.6 | 6 | Chemie (LMT) | |||
| 4 | G, X (A, C) | DECANE | non-polymer | 142.3 | 2 | Chemie (D10) | |||
| 5 | AA, BA, I, IA, JA... (C, A, E, B) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 6 | Chemie (EDO) | |||
| 6 | M (B) | (2S)-3-hydroxypropane-1,2-diyl didecanoate | non-polymer | 400.6 | 1 | Chemie (DDR) | |||
| 7 | N (B) | PENTADECANE | non-polymer | 212.4 | 1 | Chemie (MYS) | |||
| 8 | O (B) | Octadecane | non-polymer | 254.5 | 1 | Chemie (8K6) | |||
| 9 | P (B) | (4S,4AS,5AR,12AS)-4,7-BIS(DIMETHYLAMINO)-3,10,12,12A-TETRAHYDROXY-1,11-DIOXO-1,4,4A,5,5A,6,11,12A-OCTAHYDROTETRACENE-2- CARBOXAMIDE | non-polymer | 457.5 | 1 | Chemie (MIY) | |||
| 10 | CA, DA, EA, HA, Q (C, D, B) | GLYCEROL | non-polymer | 92.1 | 5 | Chemie (GOL) | |||
| 11 | R (B) | N-OCTANE | non-polymer | 114.2 | 1 | Chemie (OCT) | |||
| 12 | GA, T, U (C, B) | SULFATE ION | non-polymer | 96.1 | 3 | Chemie (SO4) | |||
| 13 | V (C) | DODECANE | non-polymer | 170.3 | 1 | Chemie (D12) | |||
| 14 | Y (C) | PHOSPHATIDYLETHANOLAMINE | non-polymer | 734.0 | 1 | Chemie (PTY) | |||
| 15 | Z (C) | TETRADECANE | non-polymer | 198.4 | 1 | Chemie (C14) | |||
| 16 | FA (C) | DECYLAMINE-N,N-DIMETHYL-N-OXIDE | non-polymer | 201.3 | 1 | Chemie (DDQ) | |||
| 17 | KA, LA, MA, NA, OA (A, B, C, D, E) | water | water | 18.0 | 133 | Chemie (HOH) |
Sequence modifications
A, B, C: 1 - 1049 (UniProt: P31224)
| PDB | External Database | Details |
|---|---|---|
| Phe 38 | Ile 38 | engineered mutation |
| Thr 671 | Ile 671 | engineered mutation |
| Leu 1050 | - | expression tag |
| Glu 1051 | - | expression tag |
| His 1052 | - | expression tag |
| His 1053 | - | expression tag |
| His 1054 | - | expression tag |
| His 1055 | - | expression tag |
| His 1056 | - | expression tag |
| His 1057 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 380909.9 | |
| Non-Polymers* | Number of molecules | 31 |
| Total formula weight | 7212.6 | |
| All* | Total formula weight | 388122.5 |
