6ZO5
Fusidic acid binding to the TM1/TM2 groove of AcrB-G619P_G621P
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (A, B, C) | Multidrug efflux pump subunit AcrB | polymer | 1057 | 114816.4 | 3 | UniProt (P31224) Pfam (PF00873) | Escherichia coli K-12 | AcrAB-TolC multidrug efflux pump subunit AcrB,Acridine resistance protein B |
| 2 | D, E (D, E) | DARPIN | polymer | 169 | 18317.6 | 2 | synthetic construct | ||
| 3 | F (A) | 3,6,9,12,15,18,21,24,27-NONAOXANONACOSANE-1,29-DIOL | non-polymer | 458.5 | 1 | Chemie (XPE) PubChem (79689) | |||
| 4 | G, H, I, J, RA... (A, C, B) | DODECYL-BETA-D-MALTOSIDE | non-polymer | 510.6 | 8 | Chemie (LMT) | |||
| 5 | K, L, SA, Z (A, C, B) | DODECANE | non-polymer | 170.3 | 4 | Chemie (D12) PubChem (8182) PubChem (5359624) | |||
| 6 | BA, CA, M, N, VA (B, A, C) | DECANE | non-polymer | 142.3 | 5 | Chemie (D10) PubChem (15600) | |||
| 7 | AB, FA, O, P, Q... (C, B, A) | GLYCEROL | non-polymer | 92.1 | 8 | Chemie (GOL) PubChem (753) | |||
| 8 | BB, CB, GA, HA, IA... (C, B, A) | HEXANE | non-polymer | 86.2 | 7 | Chemie (HEX) PubChem (8058) | |||
| 9 | EB, FB, GB, JA, KA... (C, D, B, A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 7 | Chemie (EDO) | |||
| 10 | U (B) | (2S)-3-hydroxypropane-1,2-diyl didecanoate | non-polymer | 400.6 | 1 | Chemie (DDR) PubChem (162916) PubChem (10834862) PubChem (1321) | |||
| 11 | V (B) | FUSIDIC ACID | non-polymer | 516.7 | 1 | Chemie (FUA) PubChem (3443) PubChem (3032280) PubChem (5820788) PubChem (6604483) PubChem (6914278) PubChem (11466473) PubChem (11973017) PubChem (12110530) PubChem (12305061) PubChem (21148423) PubChem (23636770) PubChem (23637137) PubChem (23639198) PubChem (23639553) PubChem (24867849) PubChem (176519951) PubChem (44655892) PubChem (16757684) PubChem (18530307) PubChem (20639055) PubChem (22800304) PubChem (24871020) PubChem (44345525) PubChem (46781674) PubChem (49868174) PubChem (3032525) PubChem (57373456) PubChem (60138401) PubChem (68099750) PubChem (70684533) PubChem (3000226) PubChem (3001077) PubChem (23423) PubChem (244879) PubChem (71315981) PubChem (71317019) PubChem (73952088) PubChem (89877076) PubChem (90660382) PubChem (90697437) PubChem (5280986) PubChem (5288270) PubChem (5353638) PubChem (53911549) PubChem (53911550) PubChem (6604105) PubChem (124291107) PubChem (124900075) PubChem (124900734) PubChem (124900071) PubChem (124900730) PubChem (124921605) PubChem (126963540) PubChem (57312976) PubChem (134694339) PubChem (11957550) PubChem (12305058) PubChem (12305062) PubChem (137703527) PubChem (142165976) PubChem (154790121) PubChem (58872606) PubChem (161670019) PubChem (163002326) PubChem (171153990) PubChem (175673725) PubChem (60138404) PubChem (66593017) PubChem (73759677) PubChem (73952461) PubChem (90660452) PubChem (90660516) PubChem (91122380) PubChem (91450867) PubChem (91873262) PubChem (118855441) PubChem (123332703) PubChem (124291106) PubChem (124833740) PubChem (124833741) PubChem (124867503) PubChem (124900073) PubChem (124900076) PubChem (124900732) PubChem (124900735) PubChem (124921604) PubChem (124932933) PubChem (124932934) PubChem (125032759) PubChem (126968843) PubChem (131707593) PubChem (132342643) PubChem (133688410) PubChem (157247173) PubChem (163002324) PubChem (163002325) PubChem (163002327) PubChem (163002328) PubChem (163002329) PubChem (163002330) PubChem (163002331) PubChem (165429846) PubChem (166948652) PubChem (172012042) | |||
| 12 | AA, TA, UA (B, C) | TETRADECANE | non-polymer | 198.4 | 3 | Chemie (C14) PubChem (12389) | |||
| 13 | DA, EA, WA (B, C) | SULFATE ION | non-polymer | 96.1 | 3 | Chemie (SO4) | |||
| 14 | MA, OA (C) | (2S)-3-{[(R)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-hydroxypropyl hexadecanoate | non-polymer | 453.6 | 2 | Chemie (LPX) PubChem (89229) PubChem (9547069) PubChem (25229539) | |||
| 15 | NA, PA (C) | TRIETHYLENE GLYCOL | non-polymer | 150.2 | 2 | Chemie (PGE) | |||
| 16 | QA (C) | PHOSPHATIDYLETHANOLAMINE | non-polymer | 734.0 | 1 | Chemie (PTY) PubChem (446872) PubChem (3330137) | |||
| 17 | DB (C) | N-OCTANE | non-polymer | 114.2 | 1 | Chemie (OCT) PubChem (356) | |||
| 18 | HB, IB, JB, KB, LB (A, B, C, D, E) | water | water | 18.0 | 844 | Chemie (HOH) |
Sequence modifications
A, B, C: 1 - 1049 (UniProt: P31224)
| PDB | External Database | Details |
|---|---|---|
| Pro 619 | Gly 619 | engineered mutation |
| Pro 621 | Gly 621 | engineered mutation |
| Leu 1050 | - | expression tag |
| Glu 1051 | - | expression tag |
| His 1052 | - | expression tag |
| His 1053 | - | expression tag |
| His 1054 | - | expression tag |
| His 1055 | - | expression tag |
| His 1056 | - | expression tag |
| His 1057 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 381084.4 | |
| Non-Polymers* | Number of molecules | 54 |
| Total formula weight | 11567.0 | |
| All* | Total formula weight | 392651.4 |
