6ZND
[1,2,4]Triazolo[1,5-a]pyrimidine Phosphodiesterase 2 Inhibitors
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | cGMP-dependent 3',5'-cyclic phosphodiesterase | polymer | 353 | 41432.4 | 2 | UniProt (O00408) Pfam (PF00233) In PDB | Homo sapiens (Human) | Cyclic GMP-stimulated phosphodiesterase,cGSPDE |
2 | A, B | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
3 | A, B | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
4 | A, B | [(3~{S})-3-([1,2,4]triazolo[1,5-a]pyrimidin-7-yl)piperidin-1-yl]-(3,4,5-trimethoxyphenyl)methanone | non-polymer | 397.4 | 2 | Chemie (QMZ) | |||
5 | water | water | 18.0 | 201 | Chemie (HOH) |
Sequence modifications
A, B: 578 - 921 (UniProt: O00408)
PDB | External Database | Details |
---|---|---|
Met 576 | - | initiating methionine |
Gly 577 | - | expression tag |
Arg 922 | - | expression tag |
His 923 | - | expression tag |
His 924 | - | expression tag |
His 925 | - | expression tag |
His 926 | - | expression tag |
His 927 | - | expression tag |
His 928 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 82864.8 | |
Non-Polymers* | Number of molecules | 6 |
Total formula weight | 974.3 | |
All* | Total formula weight | 83839.0 |