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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

6ZMW

Structure of a human 48S translational initiation complex

This is a non-PDB format compatible entry.
Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
12Eukaryotic translation initiation factor 3 subunit Ipolymer32536543.81UniProt (Q13347)
Pfam (PF00400)
Pfam (PF12894)
In PDB		Homo sapiens (Human)eIF3i,Eukaryotic translation initiation factor 3 subunit 2,TGF-beta receptor-interacting protein 1,TRIP-1,eIF-3-beta,eIF3 p36
21Eukaryotic translation initiation factor 3 subunit Bpolymer81492593.41UniProt (P55884)
Pfam (PF00076)
Pfam (PF08662)
In PDB		Homo sapiens (Human)eIF3b,Eukaryotic translation initiation factor 3 subunit 9,Prt1 homolog,hPrt1,eIF-3-eta,eIF3 p110,eIF3 p116
36Eukaryotic translation initiation factor 3 subunit Mpolymer37442555.81UniProt (Q7L2H7)
Pfam (PF01399)
Pfam (PF18005)
In PDB		Homo sapiens (Human)eIF3m,Fetal lung protein B5,hFL-B5,PCI domain-containing protein 1
44Eukaryotic translation initiation factor 3 subunit Fpolymer35737593.61UniProt (O00303)
Pfam (PF01398)
Pfam (PF13012)
In PDB		Homo sapiens (Human)eIF3f,Deubiquitinating enzyme eIF3f,Eukaryotic translation initiation factor 3 subunit 5,eIF-3-epsilon,eIF3 p47
5uEukaryotic translation initiation factor 3 subunit Apolymer1382166903.81UniProt (Q14152)
Pfam (PF22591)
Pfam (PF01399)
In PDB		Homo sapiens (Human)eIF3a,Eukaryotic translation initiation factor 3 subunit 10,eIF-3-theta,eIF3 p167,eIF3 p180,eIF3 p185
6vEukaryotic translation initiation factor 3 subunit Epolymer44552281.61UniProt (P60228)
Pfam (PF09440)
Pfam (PF01399)
Pfam (PF21357)
In PDB		Homo sapiens (Human)eIF3e,Eukaryotic translation initiation factor 3 subunit 6,Viral integration site protein INT-6 homolog,eIF-3 p48
7S40S ribosomal protein S6polymer24928751.91UniProt (P62753)
Pfam (PF01092)
In PDB		Homo sapiens (Human)Phosphoprotein NP33,Small ribosomal subunit protein eS6
8yEukaryotic translation initiation factor 3 subunit Cpolymer913105503.91UniProt (Q99613)
Pfam (PF05470)
Pfam (PF01399)
In PDB		Homo sapiens (Human)eIF3c,Eukaryotic translation initiation factor 3 subunit 8,eIF3 p110
98Eukaryotic translation initiation factor 3 subunit Hpolymer35239979.31UniProt (O15372)
Pfam (PF01398)
Pfam (PF19445)
In PDB		Homo sapiens (Human)eIF3h,Eukaryotic translation initiation factor 3 subunit 3,eIF-3-gamma,eIF3 p40 subunit
10G40S ribosomal protein S7polymer19422168.91UniProt (P62081)
Pfam (PF01251)
In PDB		Homo sapiens (Human)Small ribosomal subunit protein eS7
11H40S ribosomal protein S27polymer849480.21UniProt (P42677)
Pfam (PF01667)
In PDB		Homo sapiens (Human)Metallopan-stimulin 1,MPS-1,Small ribosomal subunit protein eS27
12K40S ribosomal protein S21polymer839124.41UniProt (P63220)
Pfam (PF01249)
In PDB		Homo sapiens (Human)Small ribosomal subunit protein eS21
13L40S ribosomal protein S2polymer29331376.51UniProt (P15880)
Pfam (PF00333)
Pfam (PF03719)
In PDB		Homo sapiens (Human)40S ribosomal protein S4,Protein LLRep3,Small ribosomal subunit protein uS5
14O40S ribosomal protein S3apolymer26430002.11UniProt (P61247)
Pfam (PF01015)
In PDB		Homo sapiens (Human)Small ribosomal subunit protein eS1,v-fos transformation effector protein,Fte-1
15N40S ribosomal protein SApolymer29532883.91UniProt (P08865)
Pfam (PF00318)
Pfam (PF16122)
In PDB		Homo sapiens (Human)37 kDa laminin receptor precursor,37LRP,37/67 kDa laminin receptor,LRP/LR,67 kDa laminin receptor,67LR,Colon carcinoma laminin-binding protein,Laminin receptor 1,LamR,Laminin-binding protein precursor p40,LBP/p40,Multidrug resistance-associated protein MGr1-Ag,NEM/1CHD4,Small ribosomal subunit protein uS2
16Q40S ribosomal protein S26polymer11513047.51UniProt (P62854)
Pfam (PF01283)
In PDB		Homo sapiens (Human)Small ribosomal subunit protein eS26
17P40S ribosomal protein S14polymer15116302.81UniProt (P62263)
Pfam (PF00411)
In PDB		Homo sapiens (Human)Small ribosomal subunit protein uS11
18I40S ribosomal protein S13polymer15117259.41UniProt (P62277)
Pfam (PF08069)
Pfam (PF00312)
In PDB		Homo sapiens (Human)Small ribosomal subunit protein uS15
19xEukaryotic translation initiation factor 3 subunit Dpolymer54864060.81UniProt (O15371)
Pfam (PF05091)
In PDB		Homo sapiens (Human)eIF3d,Eukaryotic translation initiation factor 3 subunit 7,eIF-3-zeta,eIF3 p66
203Eukaryotic translation initiation factor 3 subunit Kpolymer21825083.61UniProt (Q9UBQ5)
Pfam (PF10075)
In PDB		Homo sapiens (Human)eIF3k,Eukaryotic translation initiation factor 3 subunit 12,Muscle-specific gene M9 protein,PLAC-24,eIF-3 p25,eIF-3 p28
215Eukaryotic translation initiation factor 3 subunit Lpolymer56466803.71UniProt (Q9Y262)
Pfam (PF10255)
In PDB		Homo sapiens (Human)eIF3l,Eukaryotic translation initiation factor 3 subunit 6-interacting protein,Eukaryotic translation initiation factor 3 subunit E-interacting protein
227mRNApolymer289172.81Homo sapiens (Human)
23960S ribosomal protein L41polymer253473.51UniProt (P62945)
Pfam (PF05162)
In PDB		Homo sapiens (Human)HG12,Large ribosomal subunit protein eL41
24A18S rRNApolymer1869603130.41Homo sapiens (Human)
25B40S ribosomal protein S11polymer15818468.81UniProt (P62280)
Pfam (PF16205)
Pfam (PF00366)
In PDB		Homo sapiens (Human)Small ribosomal subunit protein uS17
26C40S ribosomal protein S4, X isoformpolymer26329654.91UniProt (P62701)
Pfam (PF08071)
Pfam (PF00900)
Pfam (PF00467)
Pfam (PF16121)
In PDB		Homo sapiens (Human)SCR10,Single copy abundant mRNA protein,Small ribosomal subunit protein eS4
27D40S ribosomal protein S9polymer19422641.61UniProt (P46781)
Pfam (PF00163)
Pfam (PF01479)
In PDB		Homo sapiens (Human)Small ribosomal subunit protein uS4
28E40S ribosomal protein S23polymer14315844.71UniProt (P62266)
Pfam (PF00164)
In PDB		Homo sapiens (Human)Small ribosomal subunit protein uS12
29F40S ribosomal protein S30polymer596668.91UniProt (P62861)
Pfam (PF04758)
In PDB		Homo sapiens (Human)Small ribosomal subunit protein eS30
30rEukaryotic translation initiation factor 2 subunit 1polymer31536161.21UniProt (P05198)
Pfam (PF00575)
Pfam (PF07541)
In PDB		Homo sapiens (Human)Eukaryotic translation initiation factor 2 subunit alpha,eIF-2alpha
31J40S ribosomal protein S15apolymer13014865.61UniProt (P62244)
Pfam (PF00410)
In PDB		Homo sapiens (Human)Small ribosomal subunit protein uS8
32R40S ribosomal protein S8polymer20824263.41UniProt (P62241)
Pfam (PF01201)
In PDB		Homo sapiens (Human)Small ribosomal subunit protein eS8
33T40S ribosomal protein S24polymer13315463.31UniProt (P62847)
Pfam (PF01282)
In PDB		Homo sapiens (Human)Small ribosomal subunit protein eS24
34V40S ribosomal protein S5polymer20422913.51UniProt (P46782)
Pfam (PF00177)
In PDB		Homo sapiens (Human)Small ribosomal subunit protein uS7
35Y40S ribosomal protein S16polymer14616477.41UniProt (P62249)
Pfam (PF00380)
In PDB		Homo sapiens (Human)Small ribosomal subunit protein uS9
36Z40S ribosomal protein S3polymer24326729.41UniProt (P23396)
Pfam (PF07650)
Pfam (PF00189)
In PDB		Homo sapiens (Human)Small ribosomal subunit protein uS3
37a40S ribosomal protein S10polymer16518933.81UniProt (P46783)
Pfam (PF03501)
In PDB		Homo sapiens (Human)Small ribosomal subunit protein eS10
38b40S ribosomal protein S15polymer14517076.21UniProt (P62841)
Pfam (PF00203)
In PDB		Homo sapiens (Human)RIG protein,Small ribosomal subunit protein uS19
39cReceptor of activated protein C kinase 1polymer31735115.71UniProt (P63244)
Pfam (PF00400)
In PDB		Homo sapiens (Human)Cell proliferation-inducing gene 21 protein,Guanine nucleotide-binding protein subunit beta-2-like 1,Guanine nucleotide-binding protein subunit beta-like protein 12.3,Human lung cancer oncogene 7 protein,HLC-7,Receptor for activated C kinase,Small ribosomal subunit protein RACK1
40d40S ribosomal protein S19polymer14516091.61UniProt (P39019)
Pfam (PF01090)
In PDB		Homo sapiens (Human)Small ribosomal subunit protein eS19
41e40S ribosomal protein S25polymer12513776.21UniProt (P62851)
Pfam (PF03297)
In PDB		Homo sapiens (Human)Small ribosomal subunit protein eS25
42f40S ribosomal protein S18polymer15217759.81UniProt (P62269)
Pfam (PF00416)
In PDB		Homo sapiens (Human)Ke-3,Ke3,Small ribosomal subunit protein uS13
43i40S ribosomal protein S29polymer566690.81UniProt (P62273)
Pfam (PF00253)
In PDB		Homo sapiens (Human)Small ribosomal subunit protein uS14
44kUbiquitin-40S ribosomal protein S27apolymer15618004.01UniProt (P62979)
Pfam (PF00240)
Pfam (PF01599)
In PDB		Homo sapiens (Human)Ubiquitin carboxyl extension protein 80
45m40S ribosomal protein S12polymer13214539.01UniProt (P25398)
Pfam (PF01248)
In PDB		Homo sapiens (Human)Small ribosomal subunit protein eS12
46n40S ribosomal protein S28polymer697855.11UniProt (P62857)
Pfam (PF01200)
In PDB		Homo sapiens (Human)Small ribosomal subunit protein eS28
47oEukaryotic translation initiation factor 3 subunit Gpolymer32035662.01UniProt (O75821)
Pfam (PF12353)
Pfam (PF00076)
In PDB		Homo sapiens (Human)eIF3g,Eukaryotic translation initiation factor 3 RNA-binding subunit,eIF-3 RNA-binding subunit,Eukaryotic translation initiation factor 3 subunit 4,eIF-3-delta,eIF3 p42,eIF3 p44
48pEukaryotic translation initiation factor 1polymer11312752.51UniProt (P41567)
Pfam (PF01253)
In PDB		Homo sapiens (Human)eIF1,A121,Protein translation factor SUI1 homolog,Sui1iso1
49qEukaryotic translation initiation factor 1A, X-chromosomalpolymer14416488.41UniProt (P47813)
Pfam (PF01176)
In PDB		Homo sapiens (Human)eIF-1A X isoform,Eukaryotic translation initiation factor 4C,eIF-4C
50zEukaryotic translation initiation factor 3 subunit Jpolymer25829108.51UniProt (O75822)
Pfam (PF08597)
In PDB		Homo sapiens (Human)eIF3j,Eukaryotic translation initiation factor 3 subunit 1,eIF-3-alpha,eIF3 p35
51M40S ribosomal protein S17polymer13515578.21UniProt (P08708)
Pfam (PF00833)
In PDB		Homo sapiens (Human)Small ribosomal subunit protein eS17
52h40S ribosomal protein S20polymer11913398.81UniProt (P60866)
Pfam (PF00338)
In PDB		Homo sapiens (Human)Small ribosomal subunit protein uS10
53sEukaryotic translation initiation factor 2 subunit 2polymer33338454.51UniProt (P20042)
Pfam (PF01873)
In PDB		Homo sapiens (Human)Eukaryotic translation initiation factor 2 subunit beta,eIF-2-beta
54wInitiator Met-tRNA-ipolymer7524231.51GenBank (174924)Homo sapiens (Human)
55tEukaryotic translation initiation factor 2 subunit 3polymer47251178.41UniProt (P41091)
Pfam (PF00009)
Pfam (PF03144)
Pfam (PF09173)
In PDB		Homo sapiens (Human)Eukaryotic translation initiation factor 2 subunit gamma X,eIF-2gX
56jEukaryotic initiation factor 4A-Ipolymer40646207.81UniProt (P60842)
Pfam (PF00270)
Pfam (PF00271)
In PDB		Homo sapiens (Human)eIF4A-I,ATP-dependent RNA helicase eIF4A-1
57gEukaryotic translation initiation factor 4 gamma 1polymer1310145733.21UniProt (Q04637)
Pfam (PF02854)
Pfam (PF02847)
Pfam (PF02020)
In PDB		Homo sapiens (Human)eIF-4G1,p220
58Q, kZINC IONnon-polymer65.42Chemie (ZN)
59A, d, fMAGNESIUM IONnon-polymer24.389Chemie (MG)
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains57
Total formula weight2400866.1
Non-Polymers*Number of molecules91
Total formula weight2294.0
All*Total formula weight2403160.0
*Water molecules are not included.

223166

PDB entries from 2024-07-31

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