6ZMN
Crystal structure of the Smad3-Smad5 MH1 domain chimera bound to the GGCGC site
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Mothers against decapentaplegic homolog 3 | polymer | 125 | 14673.1 | 2 | UniProt (P84022) Pfam (PF03165) | Homo sapiens (Human) | hMAD-3,JV15-2,SMAD family member 3,hSMAD3 |
| 2 | C, D (C, D) | DNA (5'-D(P*TP*GP*CP*AP*GP*GP*CP*GP*CP*GP*CP*CP*TP*GP*CP*A)-3') | polymer | 16 | 4900.2 | 2 | Homo sapiens | ||
| 3 | E (A) | ACETATE ION | non-polymer | 59.0 | 1 | Chemie (ACT) | |||
| 4 | F (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 1 | Chemie (EDO) | |||
| 5 | G, I (A, B) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 6 | H (B) | TRIETHYLENE GLYCOL | non-polymer | 150.2 | 1 | Chemie (PGE) | |||
| 7 | J, K, L, M (A, B, C, D) | water | water | 18.0 | 16 | Chemie (HOH) |
Sequence modifications
A, B: 10 - 133 (UniProt: P84022)
| PDB | External Database | Details |
|---|---|---|
| Gly 9 | - | expression tag |
| Ala 11 | Ile 11 | conflict |
| Gln 20 | Lys 20 | conflict |
| Asp 22 | Glu 22 | conflict |
| Glu 23 | Gln 23 | conflict |
| - | Asn 24 | deletion |
| - | Gly 25 | deletion |
| - | Gln 26 | deletion |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 39146.6 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 402.1 | |
| All* | Total formula weight | 39548.7 |
