6ZKX

Crystal structure of InhA:01 TCR in complex with HLA-E (Y84C) bound to InhA (53-61 GCG)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	HLA class I histocompatibility antigen, alpha chain E	polymer	277	31895.2	1	UniProt (P13747) Pfam (PF00129) Pfam (PF07654) In PDB	Homo sapiens (Human)	MHC class I antigen E
2	B	Beta-2-microglobulin	polymer	100	11879.4	1	UniProt (P61769) Pfam (PF07654) In PDB	Homo sapiens (Human)
3	C	Enoyl-[acyl-carrier-protein] reductase [NADH]	polymer	12	1197.5	1	UniProt (P9WGR1) In PDB	Mycobacterium tuberculosis H37Rv	Enoyl-ACP reductase,FAS-II enoyl-ACP reductase,NADH-dependent 2-trans-enoyl-ACP reductase
4	D	T-cell receptor alpha chain	polymer	199	21496.7	1		Homo sapiens (Human)
5	E	T-cell receptor beta chain	polymer	245	27491.5	1		Homo sapiens (Human)
6	A, B, D	1,2-ETHANEDIOL	non-polymer		62.1	8	Chemie (EDO)
7		water	water		18.0	257	Chemie (HOH)

Sequence modifications

A: 1 - 276 (UniProt: P13747)

PDB	External Database	Details
Met 0	-	initiating methionine
Cys 84	Tyr 105	engineered mutation

B: 3 - 101 (UniProt: P61769)

PDB	External Database	Details
Met 2	-	initiating methionine

C: 1 - 12 (UniProt: P9WGR1)

PDB	External Database	Details
Gly 10	Glu 62	engineered mutation
Cys 11	Leu 63	engineered mutation
Gly 12	Asp 64	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	5
	Total formula weight	93960.3
Non-Polymers*	Number of molecules	8
	Total formula weight	496.5
All*	Total formula weight	94456.8

*Water molecules are not included.