6ZIS
Crystal structure of a CGRP receptor ectodomain heterodimer with bound high affinity inhibitor
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Maltose/maltodextrin-binding periplasmic protein,Receptor activity-modifying protein 1,Calcitonin gene-related peptide type 1 receptor | polymer | 594 | 66360.6 | 1 | UniProt (P0AEX9) UniProt (O60894) UniProt (Q16602) Pfam (PF01547) Pfam (PF04901) Pfam (PF02793) UniProt (by SIFTS) (A0A4P1LXE0) In PDB | Escherichia coli (strain K12) | MMBP,Maltodextrin-binding protein,Maltose-binding protein,MBP,Calcitonin-receptor-like receptor activity-modifying protein 1,CRLR activity-modifying protein 1,CGRP type 1 receptor,Calcitonin receptor-like receptor |
2 | B | alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose | branched | 342.3 | 1 | In PDB BIRD (PRD_900001) GlyTouCan (G07411ON) | alpha-maltose | ||
3 | A | TETRAETHYLENE GLYCOL | non-polymer | 194.2 | 3 | Chemie (PG4) | |||
4 | A | N-{(1S)-5-amino-1-[(4-pyridin-4-ylpiperazin-1-yl)carbonyl]pentyl}-3,5-dibromo-Nalpha-{[4-(2-oxo-1,4-dihydroquinazolin-3 (2H)-yl)piperidin-1-yl]carbonyl}-D-tyrosinamide | non-polymer | 869.6 | 1 | Chemie (3N6) | |||
5 | water | water | 18.0 | 282 | Chemie (HOH) |
Sequence modifications
A: 2 - 368 (UniProt: P0AEX9)
A: 1024 - 1111 (UniProt: O60894)
A: 2029 - 2144 (UniProt: Q16602)
PDB | External Database | Details |
---|---|---|
Ala 0 | - | expression tag |
Ser 1 | - | expression tag |
Asn 369 | - | linker |
Ala 370 | - | linker |
Ala 371 | - | linker |
Ala 372 | - | linker |
Glu 1022 | - | linker |
Phe 1023 | - | linker |
PDB | External Database | Details |
---|---|---|
Gly 2020 | - | linker |
Ser 2021 | - | linker |
Ala 2022 | - | linker |
Gly 2023 | - | linker |
Ser 2024 | - | linker |
Ala 2025 | - | linker |
Gly 2026 | - | linker |
Ser 2027 | - | linker |
Ala 2028 | - | linker |
PDB | External Database | Details |
---|---|---|
Gln 2066 | Asn 66 | conflict |
Gln 2118 | Asn 118 | conflict |
Asp 2123 | Asn 123 | conflict |
His 2145 | - | expression tag |
His 2146 | - | expression tag |
His 2147 | - | expression tag |
His 2148 | - | expression tag |
His 2149 | - | expression tag |
His 2150 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 66360.6 | |
Branched | Number of molecules | 1 |
Total formula weight | 342.3 | |
Non-Polymers* | Number of molecules | 4 |
Total formula weight | 1452.3 | |
All* | Total formula weight | 68155.2 |