6ZGV

Structure of human galactokinase 1 bound with 2-(4-chlorophenyl)-N-(pyrimidin-2-yl)acetamide

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, E, D	Galactokinase	polymer	399	43103.0	4	UniProt (P51570) Pfam (PF10509) Pfam (PF00288) Pfam (PF08544) In PDB	Homo sapiens (Human)	Galactose kinase
2	A, B, E	beta-D-galactopyranose	non-polymer		180.2	3	Chemie (GAL)
3	A, B, E	2-(1,3-benzoxazol-2-ylamino)spiro[1,6,7,8-tetrahydroquinazoline-4,1'-cyclohexane]-5-one	non-polymer		350.4	3	Chemie (HFK)
4	D	2-(4-chlorophenyl)-~{N}-pyrimidin-2-yl-ethanamide	non-polymer		247.7	1	Chemie (QKZ)
5		water	water		18.0	437	Chemie (HOH)

Sequence modifications

A, B, E, D: 2 - 392 (UniProt: P51570)

PDB	External Database	Details
Met -6	-	initiating methionine
Ala -5	-	expression tag
His -4	-	expression tag
His -3	-	expression tag
His -2	-	expression tag
His -1	-	expression tag
His 0	-	expression tag
His 1	-	expression tag
Ala 252	Lys 252	engineered mutation
Ala 253	Glu 253	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	172411.9
Non-Polymers*	Number of molecules	7
	Total formula weight	1839.4
All*	Total formula weight	174251.3

*Water molecules are not included.