6ZFZ
Structure of M1-StaR-T4L in complex with 77-LH-28-1 at 2.17A
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Muscarinic acetylcholine receptor M1,Endolysin,Muscarinic acetylcholine receptor M1 | polymer | 455 | 51833.4 | 1 | UniProt (P11229) UniProt (P00720) Pfam (PF00001) Pfam (PF00959) In PDB | Homo sapiens (Human) | Lysis protein,Lysozyme,Muramidase |
2 | A | 1-[3-(4-butylpiperidin-1-yl)propyl]-3,4-dihydroquinolin-2-one | non-polymer | 328.5 | 1 | Chemie (QJT) | |||
3 | A | OLEIC ACID | non-polymer | 282.5 | 8 | Chemie (OLA) | |||
4 | A | PHOSPHATE ION | non-polymer | 95.0 | 1 | Chemie (PO4) | |||
5 | A | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate | non-polymer | 356.5 | 1 | Chemie (OLC) | |||
6 | A | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID | non-polymer | 238.3 | 1 | Chemie (EPE) | |||
7 | A | TRIETHYLENE GLYCOL | non-polymer | 150.2 | 2 | Chemie (PGE) | |||
8 | water | water | 18.0 | 33 | Chemie (HOH) |
Sequence modifications
A: 27 - 219 (UniProt: P11229)
A: 1002 - 1161 (UniProt: P00720)
A: 354 - 438 (UniProt: P11229)
PDB | External Database | Details |
---|---|---|
Met 20 | - | initiating methionine |
Glu 21 | - | expression tag |
Thr 22 | - | expression tag |
Val 23 | - | expression tag |
Glu 24 | - | expression tag |
Met 25 | - | expression tag |
Val 26 | - | expression tag |
Ala 27 | Phe 27 | engineered mutation |
Ala 29 | Gly 29 | conflict |
Thr 30 | Ile 30 | conflict |
Val 31 | Thr 31 | conflict |
Ala 32 | Thr 32 | engineered mutation |
Ile 44 | Leu 44 | engineered mutation |
Leu 46 | Val 46 | engineered mutation |
Met 47 | Leu 47 | conflict |
Leu 48 | Ile 48 | conflict |
Ile 50 | Phe 50 | conflict |
Arg 54 | Thr 54 | conflict |
Gln 55 | Glu 55 | conflict |
Gln 57 | Lys 57 | conflict |
Ala 64 | Leu 64 | engineered mutation |
Phe 65 | Leu 65 | conflict |
Ala 76 | Thr 76 | engineered mutation |
Val 84 | Thr 84 | engineered mutation |
Ile 86 | Leu 86 | conflict |
Ile 87 | Leu 87 | conflict |
Ala 95 | Thr 95 | engineered mutation |
Ala 101 | Trp 101 | engineered mutation |
Ala 112 | Ser 112 | engineered mutation |
Leu 143 | Ala 143 | engineered mutation |
Thr 196 | Ala 196 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Gly 1012 | Arg 12 | conflict |
Thr 1054 | Cys 54 | conflict |
Ala 1097 | Cys 97 | conflict |
Arg 1137 | Ile 137 | conflict |
PDB | External Database | Details |
---|---|---|
Ala 362 | Lys 362 | engineered mutation |
Leu 364 | Ala 364 | engineered mutation |
Ala 411 | Ser 411 | engineered mutation |
Ala 435 | Cys 435 | conflict |
His 439 | - | expression tag |
His 440 | - | expression tag |
His 441 | - | expression tag |
His 442 | - | expression tag |
His 443 | - | expression tag |
His 444 | - | expression tag |
His 445 | - | expression tag |
His 446 | - | expression tag |
His 447 | - | expression tag |
His 448 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 51833.4 | |
Non-Polymers* | Number of molecules | 14 |
Total formula weight | 3578.3 | |
All* | Total formula weight | 55411.8 |