6ZCX

SYK Kinase domain in complex with azabenzimidazole inhibitor 18

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Tyrosine-protein kinase SYK	polymer	299	34881.0	1	UniProt (P43405) Pfam (PF07714) In PDB	Homo sapiens (Human)	Spleen tyrosine kinase,p72-Syk
2	A	~{N},1-dimethyl-5-[[4-[3-methyl-4-[[(3~{R})-piperidin-3-yl]amino]pyrazol-1-yl]pyrimidin-2-yl]amino]indazole-3-carboxamide	non-polymer		460.5	1	Chemie (QFQ)
3		water	water		18.0	309	Chemie (HOH)

Sequence modifications

A: 343 - 635 (UniProt: P43405)

PDB	External Database	Details
His 636	-	expression tag
His 637	-	expression tag
His 638	-	expression tag
His 639	-	expression tag
His 640	-	expression tag
His 641	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	34881.0
Non-Polymers*	Number of molecules	1
	Total formula weight	460.5
All*	Total formula weight	35341.5

*Water molecules are not included.