6ZCS

SYK Kinase domain in complex with azabenzimidazole inhibitor 3

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Tyrosine-protein kinase SYK	polymer	299	34881.0	1	UniProt (P43405) Pfam (PF07714)	Homo sapiens (Human)	Spleen tyrosine kinase,p72-Syk
2	B (A)	(3~{R},4~{R})-~{N}4-[1-[2-(1-methylindol-4-yl)-3~{H}-imidazo[4,5-b]pyridin-7-yl]pyrazol-4-yl]oxane-3,4-diamine	non-polymer		428.5	1	Chemie (QFE)
3	C (A)	water	water		18.0	350	Chemie (HOH)

Sequence modifications

A: 343 - 635 (UniProt: P43405)

PDB	External Database	Details
His 636	-	expression tag
His 637	-	expression tag
His 638	-	expression tag
His 639	-	expression tag
His 640	-	expression tag
His 641	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	34881.0
Non-Polymers*	Number of molecules	1
	Total formula weight	428.5
All*	Total formula weight	35309.5

*Water molecules are not included.