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6ZA8

Crystal structure of the neurotensin receptor 1 in complex with the small-molecule partial agonist RTI-3a

This is a non-PDB format compatible entry.
Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1AAANeurotensin receptor type 1,Neurotensin receptor type 1,Neurotensin receptor 1 (NTSR1),Neurotensin receptor 1 (NTSR1),Neurotensin receptor type 1,Neurotensin receptor 1 (NTSR1),Neurotensin receptor 1 (NTSR1)polymer48253089.21UniProt (P20789)
Pfam (PF00001)
In PDB
Rattus norvegicus (Rat)NTR1,High-affinity levocabastine-insensitive neurotensin receptor,NTRH
2AAA(2~{S})-2-[[1-(7-chloranylquinolin-4-yl)-5-(2,6-dimethoxyphenyl)pyrazol-3-yl]carbonylamino]-4-methyl-pentanoic acidnon-polymer523.01Chemie (SR5)
Sequence modifications
AAA: 50 - 371 (UniProt: P20789)
PDBExternal DatabaseDetails
Gly 46-expression tag
Pro 47-expression tag
Gly 48-expression tag
Ser 49-expression tag
Gly 83Ser 83engineered mutation
Leu 86Ala 86engineered mutation
Arg 101Thr 101engineered mutation
Asp 103His 103engineered mutation
Tyr 105His 105engineered mutation
Phe 119Leu 119engineered mutation
Leu 121Met 121engineered mutation
Asp 124Glu 124engineered mutation
Lys 143Arg 143engineered mutation
Glu 150Asp 150engineered mutation
Val 161Ala 161engineered mutation
Leu 167Arg 167engineered mutation
Leu 213Arg 213engineered mutation
Leu 234Val 234engineered mutation
Arg 235Lys 235engineered mutation
Leu 240Val 240engineered mutation
Ala 253Ile 253engineered mutation
Ala 260Ile 260engineered mutation
Arg 262Asn 262engineered mutation
Arg 263Lys 263engineered mutation
-Glu 273deletion
-Gln 274deletion
-Gly 275deletion
-Arg 276deletion
-Val 277deletion
-Cys 278deletion
-Thr 279deletion
-Val 280deletion
-Gly 281deletion
-Thr 282deletion
-His 283deletion
-Asn 284deletion
-Gly 285deletion
-Leu 286deletion
-Glu 287deletion
-His 288deletion
-Ser 289deletion
-Thr 290deletion
Arg 305His 305engineered mutation
Val 332Cys 332engineered mutation
Ala 342Phe 342engineered mutation
Ser 354Thr 354engineered mutation
Val 358Phe 358engineered mutation
Ala 362Ser 362engineered mutation
AAA: 372 - 380 (PDB: 6ZA8)
AAA: 381 - 545 (PDB: 6ZA8)
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains1
Total formula weight53089.2
Non-Polymers*Number of molecules1
Total formula weight523.0
All*Total formula weight53612.2
*Water molecules are not included.

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PDB entries from 2024-09-11

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