6Z51
Crystal structure of CLK3 in complex with macrocycle ODS2002941
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Dual specificity protein kinase CLK3 | polymer | 360 | 42318.4 | 1 | UniProt (P49761) Pfam (PF00069) In PDB | Homo sapiens (Human) | CDC-like kinase 3 |
| 2 | A | PHOSPHATE ION | non-polymer | 95.0 | 1 | Chemie (PO4) | |||
| 3 | A | 1,2-ETHANEDIOL | non-polymer | 62.1 | 17 | Chemie (EDO) | |||
| 4 | A | N-cyclopentyl-2-[(11,15-dimethyl-10-oxo-8-oxa-2,11,15,19,21,23-hexazatetracyclo[15.6.1.13,7.020,24]pentacosa-1(23),3(25),4,6,17,20(24),21-heptaen-6-yl)oxy]acetamide | non-polymer | 521.6 | 1 | Chemie (Q8B) | |||
| 5 | water | water | 18.0 | 349 | Chemie (HOH) |
Sequence modifications
A: 127 - 484 (UniProt: P49761)
| PDB | External Database | Details |
|---|---|---|
| Ser 125 | - | expression tag |
| Met 126 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 42318.4 | |
| Non-Polymers* | Number of molecules | 19 |
| Total formula weight | 1671.7 | |
| All* | Total formula weight | 43990.2 |
