6Z4Z
Crystal structure of CLK1 in complex with macrocycle ODS2004070
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (A, B, C) | Dual specificity protein kinase CLK1 | polymer | 339 | 39581.5 | 3 | UniProt (P49759) Pfam (PF00069) | Homo sapiens (Human) | CDC-like kinase 1 |
| 2 | D, E, F, J (A, C) | PHOSPHATE ION | non-polymer | 95.0 | 4 | Chemie (PO4) | |||
| 3 | G (A) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 4 | H, I, K (A, B, C) | 7,10-Dioxa-13,17,18,21-tetrazatetracyclo[12.5.2.12,6.017,20]docosa-1(20),2(22),3,5,14(21),15,18-heptaene-5-carboxylic acid | non-polymer | 340.3 | 3 | Chemie (PQ5) | |||
| 5 | L, M, N (A, B, C) | water | water | 18.0 | 418 | Chemie (HOH) |
Sequence modifications
A, B, C: 148 - 484 (UniProt: P49759)
| PDB | External Database | Details |
|---|---|---|
| Ser -1 | - | expression tag |
| Met 0 | - | expression tag |
| Ala 432 | Arg 432 | variant |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 118744.5 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 1493.0 | |
| All* | Total formula weight | 120237.5 |
