6Z4Q
Crystal structure of the neurotensin receptor 1 in complex with the small-molecule inverse agonist SR142948A
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | AAA | Neurotensin receptor type 1,Neurotensin receptor type 1,DARPin | polymer | 482 | 53089.2 | 1 | UniProt (P20789) Pfam (PF00001) In PDB | Rattus norvegicus (Rat) | NTR1,High-affinity levocabastine-insensitive neurotensin receptor,NTRH |
| 2 | AAA | 2-[[5-(2,6-dimethoxyphenyl)-1-[4-[3-(dimethylamino)propyl-methyl-carbamoyl]-2-propan-2-yl-phenyl]pyrazol-3-yl]carbonylamino]adamantane-2-carboxylic acid | non-polymer | 685.9 | 1 | Chemie (Q6N) |
Sequence modifications
AAA: 50 - 371 (UniProt: P20789)
AAA: 381 - 545 (PDB: 6Z4Q)
| PDB | External Database | Details |
|---|---|---|
| Gly 46 | - | expression tag |
| Pro 47 | - | expression tag |
| Gly 48 | - | expression tag |
| Ser 49 | - | expression tag |
| Gly 83 | Ser 83 | engineered mutation |
| Leu 86 | Ala 86 | engineered mutation |
| Arg 101 | Thr 101 | engineered mutation |
| Asp 103 | His 103 | engineered mutation |
| Tyr 105 | His 105 | engineered mutation |
| Phe 119 | Leu 119 | engineered mutation |
| Leu 121 | Met 121 | engineered mutation |
| Asp 124 | Glu 124 | engineered mutation |
| Lys 143 | Arg 143 | engineered mutation |
| Glu 150 | Asp 150 | engineered mutation |
| Val 161 | Ala 161 | engineered mutation |
| Leu 167 | Arg 167 | engineered mutation |
| Leu 213 | Arg 213 | engineered mutation |
| Leu 234 | Val 234 | engineered mutation |
| Arg 235 | Lys 235 | engineered mutation |
| Leu 240 | Val 240 | engineered mutation |
| Ala 253 | Ile 253 | engineered mutation |
| Ala 260 | Ile 260 | engineered mutation |
| Arg 262 | Asn 262 | engineered mutation |
| Arg 263 | Lys 263 | engineered mutation |
| - | Glu 273 | deletion |
| - | Gln 274 | deletion |
| - | Gly 275 | deletion |
| - | Arg 276 | deletion |
| - | Val 277 | deletion |
| - | Cys 278 | deletion |
| - | Thr 279 | deletion |
| - | Val 280 | deletion |
| - | Gly 281 | deletion |
| - | Thr 282 | deletion |
| - | His 283 | deletion |
| - | Asn 284 | deletion |
| - | Gly 285 | deletion |
| - | Leu 286 | deletion |
| - | Glu 287 | deletion |
| - | His 288 | deletion |
| - | Ser 289 | deletion |
| - | Thr 290 | deletion |
| Arg 305 | His 305 | engineered mutation |
| Val 332 | Cys 332 | engineered mutation |
| Ala 342 | Phe 342 | engineered mutation |
| Ser 354 | Thr 354 | engineered mutation |
| Val 358 | Phe 358 | engineered mutation |
| Ala 362 | Ser 362 | engineered mutation |
| Ala 372 | - | linker |
| Glu 373 | - | linker |
| Asp 374 | - | linker |
| Leu 375 | - | linker |
| Val 376 | - | linker |
| Glu 377 | - | linker |
| Asp 378 | - | linker |
| Trp 379 | - | linker |
| Glu 380 | - | linker |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 53089.2 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 685.9 | |
| All* | Total formula weight | 53775.1 |
