6Z3G

Repulsive Guidance Molecule A (RGMA) in complex with Growth Differentiation Factor 5 (GDF5)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Growth/differentiation factor 5	polymer	117	13405.5	1	UniProt (P43026) Pfam (PF00019)	Homo sapiens (Human)	GDF-5,Bone morphogenetic protein 14,BMP-14,Cartilage-derived morphogenetic protein 1,CDMP-1,Lipopolysaccharide-associated protein 4,LPS-associated protein 4,Radotermin
2	B (B)	Repulsive guidance molecule A	polymer	106	11628.8	1	UniProt (Q96B86) Pfam (PF06535)	Homo sapiens (Human)	RGM domain family member A
3	C (A)	CITRIC ACID	non-polymer		192.1	1	Chemie (CIT) PubChem (311)

Sequence modifications

A: 387 - 501 (UniProt: P43026)

PDB	External Database	Details
Met 385	-	initiating methionine
Lys 386	-	expression tag

B: 54 - 139 (UniProt: Q96B86)

PDB	External Database	Details
Glu 43	-	expression tag
Thr 44	-	expression tag
Gly 45	-	expression tag
Ser 46	-	expression tag
Pro 47	-	expression tag
Cys 48	-	expression tag
Lys 49	-	expression tag
Ile 50	-	expression tag
Leu 51	-	expression tag
Lys 52	-	expression tag
Cys 53	-	expression tag
Gly 140	-	expression tag
Thr 141	-	expression tag
Lys 142	-	expression tag
His 143	-	expression tag
His 144	-	expression tag
His 145	-	expression tag
His 146	-	expression tag
His 147	-	expression tag
His 148	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	25034.3
Non-Polymers*	Number of molecules	1
	Total formula weight	192.1
All*	Total formula weight	25226.4

*Water molecules are not included.