6Z39
Structure of recombinant human beta-glucocerebrosidase in complex with BODIPY functionalised epoxide activity based probe
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (AAA, BBB) | Glucosylceramidase | polymer | 497 | 55640.2 | 2 | UniProt (P04062) Pfam (PF02055) Pfam (PF17189) | Homo sapiens (Human) | Acid beta-glucosidase,Alglucerase,Beta-glucocerebrosidase,Beta-GC,D-glucosyl-N-acylsphingosine glucohydrolase,Imiglucerase |
| 2 | C, D (A, B) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 2 | In PDB GlyTouCan (G42666HT) | |||
| 3 | AA, E (BBB, AAA) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 2 | Chemie (NAG) | |||
| 4 | F (AAA) | (1~{S},2~{R},3~{S},4~{R},5~{R},6~{R})-5-[[4-[4-[(12~{R})-2,2-bis(fluoranyl)-4,6,10,12-tetramethyl-1,3-diaza-2$l^{4}-boratricyclo[7.3.0.0^{3,7}]dodeca-4,6,9-trien-8-yl]butyl]-1,2,3-triazol-1-yl]methyl]-7-oxabicyclo[4.1.0]heptane-2,3,4-triol | non-polymer | 532.4 | 1 | Chemie (Q65) | |||
| 5 | CA, G (BBB, AAA) | ~{N}-[(1~{R},2~{R},3~{R},4~{S},5~{S},6~{S})-2-(hydroxymethyl)-3,4,5,6-tetrakis(oxidanyl)cyclohexyl]pentanamide | non-polymer | 277.3 | 2 | Chemie (K35) | |||
| 6 | DA, EA, FA, GA, H... (BBB, AAA) | SULFATE ION | non-polymer | 96.1 | 13 | Chemie (SO4) | |||
| 7 | KA, LA, MA, N, NA... (BBB, AAA) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 16 | Chemie (EDO) | |||
| 8 | QA, RA, SA, TA, X... (BBB, AAA) | GLYCEROL | non-polymer | 92.1 | 6 | Chemie (GOL) | |||
| 9 | Z (AAA) | GUANIDINE | non-polymer | 59.1 | 1 | Chemie (GAI) | |||
| 10 | BA (BBB) | ACETATE ION | non-polymer | 59.0 | 1 | Chemie (ACT) | |||
| 11 | UA, VA (AAA, BBB) | water | water | 18.0 | 904 | Chemie (HOH) |
Sequence modifications
AAA, BBB: 1 - 497 (UniProt: P04062)
| PDB | External Database | Details |
|---|---|---|
| His 495 | Arg 534 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 111280.3 | |
| Branched | Number of molecules | 2 |
| Total formula weight | 848.8 | |
| Non-Polymers* | Number of molecules | 42 |
| Total formula weight | 4442.0 | |
| All* | Total formula weight | 116571.2 |
