6Z2V
CLK3 A319V mutant bound with beta-carboline KH-CARB13 (Cpd 3)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Dual specificity protein kinase CLK3 | polymer | 360 | 42346.5 | 1 | UniProt (P49761) Pfam (PF00069) | Homo sapiens (Human) | CDC-like kinase 3 |
| 2 | B (A) | (4~{S})-7,8-bis(chloranyl)-9-methyl-1-oxidanylidene-spiro[2,4-dihydropyrido[3,4-b]indole-3,4'-piperidine]-4-carbonitrile | non-polymer | 363.2 | 1 | Chemie (KHC) | |||
| 3 | C (A) | POTASSIUM ION | non-polymer | 39.1 | 1 | Chemie (K) | |||
| 4 | D (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 1 | Chemie (EDO) | |||
| 5 | E (A) | water | water | 18.0 | 61 | Chemie (HOH) |
Sequence modifications
A: 127 - 484 (UniProt: P49761)
| PDB | External Database | Details |
|---|---|---|
| Ser 125 | - | expression tag |
| Met 126 | - | expression tag |
| Val 319 | Ala 467 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 42346.5 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 464.4 | |
| All* | Total formula weight | 42810.9 |
