6YYG
Crystal Structure of 5-(trifluoromethoxy)indoline-2,3-dione covalently bound to the PH domain of Bruton's tyrosine kinase mutant R28C
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Tyrosine-protein kinase BTK | polymer | 169 | 19983.0 | 4 | UniProt (Q06187) Pfam (PF00169) Pfam (PF00779) | Homo sapiens (Human) | Agammaglobulinemia tyrosine kinase,ATK,B-cell progenitor kinase,BPK,Bruton tyrosine kinase |
| 2 | E, H, K (A, B, D) | 5-(trifluoromethyloxy)-1,3-dihydroindol-2-one | non-polymer | 217.1 | 3 | Chemie (Q1B) | |||
| 3 | F, L (A, D) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 4 | G, I, J, M (A, B, C, D) | ZINC ION | non-polymer | 65.4 | 4 | Chemie (ZN) | |||
| 5 | N, O, P, Q (A, B, C, D) | water | water | 18.0 | 202 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 79932.1 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 961.7 | |
| All* | Total formula weight | 80893.7 |
