6YYF
Crystal Structure of 5-chloroindoline-2,3-dione covalently bound to the PH domain of Bruton's tyrosine kinase mutant R28C
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Tyrosine-protein kinase BTK | polymer | 169 | 19929.0 | 2 | UniProt (Q06187) Pfam (PF00169) Pfam (PF00779) | Homo sapiens (Human) | Agammaglobulinemia tyrosine kinase,ATK,B-cell progenitor kinase,BPK,Bruton tyrosine kinase |
| 2 | C, F (A, B) | 5-chloranyl-1,3-dihydroindol-2-one | non-polymer | 167.6 | 2 | Chemie (3IS) | |||
| 3 | D, G (A, B) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 4 | E, H (A, B) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 5 | I, J (A, B) | water | water | 18.0 | 104 | Chemie (HOH) |
Sequence modifications
A, B: 2 - 170 (UniProt: Q06187)
| PDB | External Database | Details |
|---|---|---|
| Cys 28 | Arg 28 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 39857.9 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 514.6 | |
| All* | Total formula weight | 40372.5 |
