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6YVX

HIF prolyl hydroxylase 2 (PHD2/ EGLN1) in complex with bicyclic BB-287

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(A)
Egl nine homolog 1polymer25228096.91UniProt (Q9GZT9)
Pfam (PF13640)
Homo sapiens (Human)Hypoxia-inducible factor prolyl hydroxylase 2,HPH-2,Prolyl hydroxylase domain-containing protein 2,PHD2,SM-20
2B
(A)
MANGANESE (II) IONnon-polymer54.91Chemie (MN)
3C
(A)
4-(isoquinolin-3-ylamino)-4-oxobutanoic acidnon-polymer244.21Chemie (2JP)
4D
(A)
BICARBONATE IONnon-polymer61.01Chemie (BCT)
5E
(A)
waterwater18.0128Chemie (HOH)
Sequence modifications
A: 181 - 426 (UniProt: Q9GZT9)
PDBExternal DatabaseDetails
Gly 175-expression tag
Ser 176-expression tag
His 177-expression tag
Met 178-expression tag
Ala 179-expression tag
Ser 180-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains1
Total formula weight28096.9
Non-Polymers*Number of molecules3
Total formula weight360.2
All*Total formula weight28457.1
*Water molecules are not included.

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PDB entries from 2024-11-20

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