6YTY
CLK3 A319V mutant bound with benzothiazole Tg003 (Cpd 2)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Dual specificity protein kinase CLK3 | polymer | 360 | 42346.5 | 1 | UniProt (P49761) Pfam (PF00069) In PDB | Homo sapiens (Human) | CDC-like kinase 3 |
| 2 | A | 1,2-ETHANEDIOL | non-polymer | 62.1 | 1 | Chemie (EDO) | |||
| 3 | A | (1~{Z})-1-(3-ethyl-5-methoxy-1,3-benzothiazol-2-ylidene)propan-2-one | non-polymer | 249.3 | 1 | Chemie (EAE) | |||
| 4 | water | water | 18.0 | 186 | Chemie (HOH) |
Sequence modifications
A: 127 - 484 (UniProt: P49761)
| PDB | External Database | Details |
|---|---|---|
| Ser 125 | - | expression tag |
| Met 126 | - | expression tag |
| Val 319 | Ala 467 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 42346.5 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 311.4 | |
| All* | Total formula weight | 42657.9 |
