6YT6
FOCAL ADHESION KINASE CATALYTIC DOMAIN IN COMPLEX WITH N-Methyl-N-(3-{[2-(2-oxo-2,3-dihydro-1H-indol-5-ylamino)-pyrimidin-4-ylamino]-methyl}-pyridin-2-yl)-methanesulfonamide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Focal adhesion kinase 1 | polymer | 282 | 32304.2 | 2 | UniProt (Q05397) Pfam (PF07714) In PDB | Homo sapiens (Human) | FADK 1,Focal adhesion kinase-related nonkinase,FRNK,Protein phosphatase 1 regulatory subunit 71,PPP1R71,Protein-tyrosine kinase 2,p125FAK,pp125FAK |
| 2 | A, B | ~{N}-methyl-~{N}-[3-[[[2-[(2-oxidanylidene-1,3-dihydroindol-5-yl)amino]pyrimidin-4-yl]amino]methyl]pyridin-2-yl]methanesulfonamide | non-polymer | 439.5 | 2 | Chemie (PKE) | |||
| 3 | A | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
| 4 | water | water | 18.0 | 361 | Chemie (HOH) |
Sequence modifications
A, B: 411 - 689 (UniProt: Q05397)
| PDB | External Database | Details |
|---|---|---|
| Gly 408 | - | expression tag |
| Ser 409 | - | expression tag |
| Gly 410 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 64608.4 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 975.0 | |
| All* | Total formula weight | 65583.5 |
