6YSQ
The hC4Nb8 complement inhibitory nanobody in complex with C4b
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, D (A, B) | Complement C4 beta chain | polymer | 656 | 71761.7 | 2 | UniProt (P0C0L4) Pfam (PF21145) Pfam (PF01835) Pfam (PF17791) Pfam (PF17789) Pfam (PF07703) UniProt (by SIFTS) (P0C0L5) | Homo sapiens (Human) | |
| 2 | B, E (C, D) | Complement C4-A alpha chain | polymer | 690 | 75509.9 | 2 | UniProt (P0C0L4) Pfam (PF00207) Pfam (PF07678) Pfam (PF22661) | Homo sapiens (Human) | |
| 3 | C, F (E, F) | Complement C4 gamma chain | polymer | 291 | 33085.6 | 2 | UniProt (P0C0L5) Pfam (PF01759) Pfam (PF07677) | Homo sapiens (Human) | |
| 4 | G, H (G, H) | hC4Nb8 nanobody | polymer | 132 | 14683.3 | 2 | Escherichia coli | ||
| 5 | I, J, K, L (I, J, K, L) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 4 | In PDB GlyTouCan (G15407YE) |
Sequence modifications
C, D: 757 - 1446 (UniProt: P0C0L4)
E, F: 1454 - 1744 (UniProt: P0C0L5)
| PDB | External Database | Details |
|---|---|---|
| Glu 1013 | Gln 1013 | variant |
| Ser 1201 | Thr 1201 | variant |
| PDB | External Database | Details |
|---|---|---|
| Asn 1735 | Gln 1735 | conflict |
| Phe 1737 | Tyr 1737 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 390081.0 | |
| Branched | Number of molecules | 4 |
| Total formula weight | 2346.2 | |
| All* | Total formula weight | 392427.1 |
