6YSQ

The hC4Nb8 complement inhibitory nanobody in complex with C4b

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Complement C4 beta chain	polymer	656	71761.7	2	UniProt (P0C0L4) Pfam (PF21145) Pfam (PF01835) Pfam (PF17791) Pfam (PF17789) Pfam (PF07703) UniProt (by SIFTS) (P0C0L5) In PDB	Homo sapiens (Human)
2	C, D	Complement C4-A alpha chain	polymer	690	75509.9	2	UniProt (P0C0L4) Pfam (PF00207) Pfam (PF07678) Pfam (PF22661) In PDB	Homo sapiens (Human)
3	E, F	Complement C4 gamma chain	polymer	291	33085.6	2	UniProt (P0C0L5) Pfam (PF01759) Pfam (PF07677) In PDB	Homo sapiens (Human)
4	G, H	hC4Nb8 nanobody	polymer	132	14683.3	2		Escherichia coli
5	I, J, K, L	beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		586.5	4	In PDB GlyTouCan (G15407YE)

Sequence modifications

C, D: 757 - 1446 (UniProt: P0C0L4)

PDB	External Database	Details
Glu 1013	Gln 1013	variant
Ser 1201	Thr 1201	variant

E, F: 1454 - 1744 (UniProt: P0C0L5)

PDB	External Database	Details
Asn 1735	Gln 1735	conflict
Phe 1737	Tyr 1737	conflict

Contents of the asymmetric unit

Polymers	Number of chains	8
	Total formula weight	390081.0
Branched	Number of molecules	4
	Total formula weight	2346.2
All*	Total formula weight	392427.1

*Water molecules are not included.