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6YK2

Structure of the AMPA receptor GluA2o ligand-binding domain (S1S2J) in complex with the compound (S)-1-[2'-Amino-2'-carboxyethyl]-5,7-dihydrothieno[3,4-d]pyrimidin- 2,4(1H,3H)-dione at resolution 1.60A

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1AGlutamate receptor 2,Glutamate receptor 2polymer26429278.71UniProt (P19491)
Pfam (PF10613)
Pfam (PF00060)
Pfam (PF00497)
In PDB
Rattus norvegicus (Rat)GluR-2,AMPA-selective glutamate receptor 2,GluR-B,GluR-K2,Glutamate receptor ionotropic,AMPA 2,GluA2
2ASULFATE IONnon-polymer96.13Chemie (SO4)
3AGLYCEROLnon-polymer92.15Chemie (GOL)
4A(2~{S})-2-azanyl-3-[2,4-bis(oxidanylidene)-5,7-dihydrothieno[3,4-d]pyrimidin-1-yl]propanoic acidnon-polymer257.31Chemie (CGW)
5ACHLORIDE IONnon-polymer35.51Chemie (CL)
6waterwater18.0342Chemie (HOH)
Sequence modifications
A: 3 - 117 (UniProt: P19491)
PDBExternal DatabaseDetails
Gly 1-expression tag
Ala 2-expression tag
A: 120 - 264 (UniProt: P19491)
PDBExternal DatabaseDetails
Gly 118-linker
Thr 119-linker
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains1
Total formula weight29278.7
Non-Polymers*Number of molecules10
Total formula weight1041.4
All*Total formula weight30320.1
*Water molecules are not included.

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PDB entries from 2024-06-12

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