6YH9
Crystal structure of chimeric carbonic anhydrase XII with 2,3,6-trifluoro-5-{[(1R,2S)-2-hydroxy-1,2-diphenylethyl]amino}-4-[(2-hydroxyethyl)sulfonyl]benzenesulfonamide
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Carbonic anhydrase 2 | polymer | 260 | 29220.9 | 1 | UniProt (P00918) Pfam (PF00194) In PDB | Homo sapiens (Human) | Carbonate dehydratase II,Carbonic anhydrase C,CAC,Carbonic anhydrase II,CA-II |
2 | A | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
3 | A | 2,3,6-trifluoro-5-{[(1R,2S)-2-hydroxy-1,2-diphenylethyl]amino}-4-[(2-hydroxyethyl)sulfonyl]benzenesulfonamide | non-polymer | 530.5 | 1 | Chemie (WWX) | |||
4 | water | water | 18.0 | 202 | Chemie (HOH) |
Sequence modifications
A: 1 - 261 (UniProt: P00918)
PDB | External Database | Details |
---|---|---|
Ser 65 | Ala 65 | engineered mutation |
Lys 67 | Asn 67 | engineered mutation |
Thr 91 | Ile 91 | engineered mutation |
Ala 131 | Phe 130 | engineered mutation |
Ser 135 | Val 134 | engineered mutation |
Asn 204 | Leu 203 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 29220.9 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 595.9 | |
All* | Total formula weight | 29816.8 |