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6YH5

Crystal structure of chimeric carbonic anhydrase XII with 2-Chloro-4-[(pyrimidin-2-ylsulfanyl)acetyl]benzenesulfonamide

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1ACarbonic anhydrase 2polymer26029220.91UniProt (P00918)
Pfam (PF00194)
In PDB
Homo sapiens (Human)Carbonate dehydratase II,Carbonic anhydrase C,CAC,Carbonic anhydrase II,CA-II
2AZINC IONnon-polymer65.41Chemie (ZN)
3A2-chloro-4-[(pyrimidin-2-ylsulfanyl)acetyl]benzenesulfonamidenon-polymer343.81Chemie (E1F)
4ABENZOIC ACIDnon-polymer122.11Chemie (BEZ)
5ADIMETHYL SULFOXIDEnon-polymer78.11Chemie (DMS)
6waterwater18.0334Chemie (HOH)
Sequence modifications
A: 1 - 261 (UniProt: P00918)
PDBExternal DatabaseDetails
Ser 65Ala 65engineered mutation
Lys 67Asn 67engineered mutation
Thr 91Ile 91engineered mutation
Ala 131Phe 130engineered mutation
Ser 135Val 134engineered mutation
Asn 204Leu 203engineered mutation
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains1
Total formula weight29220.9
Non-Polymers*Number of molecules4
Total formula weight609.5
All*Total formula weight29830.4
*Water molecules are not included.

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PDB entries from 2024-06-12

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