6YG3
Crystal structure of MKK7 (MAP2K7) covalently bound with CPT1-70-1
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Dual specificity mitogen-activated protein kinase kinase 7 | polymer | 307 | 34944.6 | 1 | UniProt (O14733) Pfam (PF00069) | Homo sapiens (Human) | MAPKK 7,JNK-activating kinase 2,MAPK/ERK kinase 7,MEK 7,Stress-activated protein kinase kinase 4,SAPKK4,c-Jun N-terminal kinase kinase 2,JNKK 2 |
| 2 | B, C, D, E, F... (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 9 | Chemie (EDO) | |||
| 3 | K (A) | N-(4-((2-((4-(4-methylpiperazin-1-yl)phenyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)oxy)phenyl)acrylamide | non-polymer | 469.5 | 1 | Chemie (6HF) | |||
| 4 | L (A) | water | water | 18.0 | 117 | Chemie (HOH) |
Sequence modifications
A: 116 - 421 (UniProt: O14733)
| PDB | External Database | Details |
|---|---|---|
| Ser 115 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 34944.6 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 1028.2 | |
| All* | Total formula weight | 35972.8 |
