6YD7
X-ray structure of furin in complex with the canavanine-based inhibitor 4-guanidinomethyl-phenylacetyl-Arg-Tle-Canavanine-Amba
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Furin | polymer | 480 | 52112.3 | 1 | UniProt (P09958) Pfam (PF00082) Pfam (PF01483) | Homo sapiens (human) | Dibasic-processing enzyme,Paired basic amino acid residue-cleaving enzyme,PACE |
| 2 | B (B) | 4-guanidinomethyl-phenylacetyl-Arg-Tle-Canavanine-Amba | polymer | 5 | 766.9 | 1 | synthetic construct | ||
| 3 | C, D, E (A) | CALCIUM ION | non-polymer | 40.1 | 3 | Chemie (CA) | |||
| 4 | F, G, H (A) | SODIUM ION | non-polymer | 23.0 | 3 | Chemie (NA) | |||
| 5 | I (A) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 6 | J, K (A) | PHOSPHATE ION | non-polymer | 95.0 | 2 | Chemie (PO4) | |||
| 7 | L (A) | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 1 | Chemie (DMS) | |||
| 8 | M, N (A, B) | water | water | 18.0 | 464 | Chemie (HOH) |
Sequence modifications
A: 108 - 574 (UniProt: P09958)
| PDB | External Database | Details |
|---|---|---|
| Ser 575 | - | expression tag |
| Gly 576 | - | expression tag |
| Ser 577 | - | expression tag |
| Leu 578 | - | expression tag |
| Val 579 | - | expression tag |
| Pro 580 | - | expression tag |
| Arg 581 | - | expression tag |
| Gly 582 | - | expression tag |
| Ser 583 | - | expression tag |
| His 584 | - | expression tag |
| His 585 | - | expression tag |
| His 586 | - | expression tag |
| His 587 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 52879.2 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 492.7 | |
| All* | Total formula weight | 53372.0 |
